硫辛酸对糖尿病肾病患者氧化应激水平的影响  

Effects of lipoic acid on oxidative stress in patients with diabetic nephropathy

作　　者：李荣红[1] Li Roughong(Department of Endocrinology, Lin fen People's Hospital, Linfen 041000, China)

机构地区：[1]山西省临汾市人民医院内分泌科,041000

出　　处：《中国实用医刊》2019年第1期115-118,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨糖尿病肾病患者经硫辛酸治疗后其氧化应激水平的变化情况。方法回顾性分析2016年10月至2018年1月在临汾市人民医院治疗的80例糖尿病肾病患者的临床资料,根据治疗方案分为硫辛酸组(37例)与常规治疗组(43例)。比较两组氧化应激水平[超氧化物歧化酶(SOD)、丙二醛(MDA)、血红素加氧酶-1(HO-1)]、肱动脉血流介导扩张(FMD)值及炎性反应指标[超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、趋化因子配体2(CCL2)]。结果治疗前,两组SOD、HO-1、MDA水平比较差异未见统计学意义(P>0.05);治疗后2个月,硫辛酸组SOD、HO-1水平高于常规治疗组,MDA水平低于常规治疗组,差异有统计学意义(P<0.05)。治疗前,两组FMD值比较差异未见统计学意义(P>0.05);治疗后2个月,硫辛酸组FMD值低于常规治疗组,差异有统计学意义(P<0.05)。治疗前,两组hs-CRP、TNF-α、CCL2水平比较差异未见统计学意义(P>0.05);治疗后,硫辛酸组hs-CRP、TNF-α、CCL2水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组尿微量白蛋白比较差异未见统计学意义(P>0.05);治疗后,硫辛酸组尿微量白蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论糖尿病肾病患者采用硫辛酸治疗,可有效提高抗氧化应激能力,利于保护其血管内皮功能,调节肾功能指标,减少尿微量白蛋白,缓解炎性反应。Objective To investigate the changes of oxidative stress in diabetic nephropathy patients after lipoic acid treatment. Methods The clinical data of 80 patients with diabetic nephropathy treated in Linfen People’s Hospital from October 2016 to January 2018 were retrospectively analyzed. According to treatment protocols, patients were divided into lipoic acid group (37 cases) and routine treatment group (43 cases). The level of oxidative stress, including superoxide dismutase (SOD), malondialdehyde (MDA), heme oxygenase-1 (HO-1), brachial artery blood flow mediated dilation (FMD) and inflammatory response index, such as high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α(TNF-α), chemokine ligand 2 (CCL2), were compared between the two groups. Results Before treatment, there was no significant difference in levels of SOD, HO-1 or MDA between the two groups (P>0.05);after 2 months of treatment, the levels of SOD and HO-1 in lipoic acid group were higher than those in conventional treatment group, and the MDA level was lower than that in conventional treatment group (P<0.05). Before treatment, the difference in FMD values between the two groups was not statistically significant (P>0.05);after 2 months of treatment, the FMD value of lipoic acid group was lower than that of conventional treatment group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in levels of hs-CRP, TNF-α, or CCL2 between the two groups (P>0.05);after treatment, the levels of hs-CRP, TNF-α and CCL2 in lipoic acid group were lower than those in conventional treatment group (P<0.05). Before treatment, the difference of urine microalbuminuria between the two groups was not statistically significant (P>0.05);after treatment, the level of microalbuminuria in lipoic acid group was lower than that in conventional treatment group, and the difference was statistically significant (P<0.05). Conclusions Thioctanoic acid in the treatment of diabetic nephropathy patients ca

关 键 词：糖尿病肾病 硫辛酸 氧化应激水平 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]