参附注射液联合生脉注射液对急性心力衰竭无创正压通气患者呼吸功能的影响  

Effect of Shenfu Injection Combined with Shengmai Injection on Respiratory Function of Patients with Acute Heart Failure in Noninvasive Positive Pressure Ventilation

作　　者：陈景利[1] 李旷怡[1] 何明丰[1] 刘绍辉[1] 张英俭[1] 梁章荣[1] 彭嘉健 CHEN Jingli;LI Kuangyi;HE Mingfeng;LIU Shaohui;ZHANG Yingjian;LIANG Zhangrong;PENG Jiajian(Department of Emerge ncy,Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Foshan 528000,Guangdong Province,China)

机构地区：[1]广州中医药大学附属佛山市中医院急诊科,广东佛山528000

出　　处：《长春中医药大学学报》2019年第1期52-54,共3页Journal of Changchun University of Chinese Medicine

基　　金：广东省中医药管理局科研项目(20132031);佛山市卫生局科研项目(2014126);佛山市重点专科培育建设项目(Fspy2-2015004);佛山市十三五高水平重点专科建设项目(FSGSPZD135025)

摘　　要：目的探讨参附注射液联合生脉注射液对急性心力衰竭(AHF)无创正压通气患者呼吸功能的影响。方法采用随机数字表法将120例急性心力衰竭无创正压通气患者分为常规组、参附组、生脉组、参附联合生脉组(联合组),各30名,分别给予常规西药治疗,以及在常规组基础上加用参附注射液、生脉注射液、参附注射液联合生脉注射液静脉输注,观察4组的临床症状缓解时间、临床疗效、血气分析及NT-pro BNP指标。结果联合组临床疗效较佳,其临床症状改善时间较其它3组有明显缩短,治疗后血浆NT-proBNP、PaCO_2、PaO_2水平比其它3组改善得更明显,差异有统计学意义(P <0.05);4组治疗后pH水平较治疗前升高,但各组间比较差异无统计学意义(P> 0.05)。结论参附注射液与生脉注射液治疗急性心力衰竭有协同作用,联合使用治疗急性心力衰竭无创正压通气患者能更快缓解临床症状,明显改善呼吸功能,提高疗效,值得临床推广应用。Objective To investigate the effects of Shenfu Injection combined with Shengmai Injection on respiratory function in patients with acute heart failure (AHF) treated in noninvasive positive pressure ventilation (NPPV). Methods 120 patients with AHF in NPPV were divided into routine group, Shenfu group, Shengmai group and Shenfu Shengmai group (combined group) by random digital table. 30 patients in each group were treated with conventional western medicine, plus Shenfu injection, Shengmai injection, and Shenfu injection combined with Shengmai injection on the basis of routine group. The clinical symptoms, remission time, clinical efficacy, blood gas analysis and NT-proBNP index of the four groups were observed. Results The clinical curative effect of the combined group was better than the other three groups. The plasma NT-proBNP, PaCO2 and PaO2 levels were better than the other three groups after treatment (P<0.05). The level of pH in the four groups has improvement, but there was no difference between the groups (all P>0.05). Conclusion Shenfu Injection and Shengmai Injection have synergistic effect in the treatment of AHF. Combined use in the treatment of patients with AHF can relieve clinical symptoms faster, improve respiratory function obviously and improve curative effect. It is worthy of clinical application.

关 键 词：急性心力衰竭 无创正压通气 参附注射液 生脉注射液 

分 类 号：R259[医药卫生—中西医结合]