黄芪酸枣仁汤治疗甲状腺功能亢进症  

Huangqi Suanzaoren Decoction in Treatment of Hyperthyroidism

作　　者：徐娜[1] 何小景 刚新玲 付丽萍 XU Na;HE Xiaojing;GANG Xinling;FU Liping(Nanyang Hospital Affiliated to Zhengzhou University/Nanyang Central Hospital,Nanyang Henan China 473009)

机构地区：[1]郑州大学附属南阳医院/南阳市中心医院,河南南阳473009

出　　处：《中医学报》2019年第2期375-378,共4页Acta Chinese Medicine

基　　金：国家自然科学基金项目(81372863)

摘　　要：目的:观察黄芪酸枣仁汤治疗甲状腺功能亢进症的临床评疗效对甲状腺体积的影响。方法:90例甲状腺功能亢进症患者作随机分为观察组(n=45)和对照组(n=45)。对照组根据病情程度,每日口服30～60 mg甲巯咪唑;观察组在对照组治疗基础上给予黄芪酸枣仁汤治疗。两组患者均连续治疗8周。比较两组患者治疗前后血清甲状腺素、甲状腺体积、中医证候积分,并比较两组治疗后临床疗效和治疗过程中的不良反应。结果:治疗后,两组患者血清游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)均显著降低,促甲状腺激素(thyrotropic hormone,TSH)显著升高,差异均有统计学意义(P<0.05);观察组血清FT3、FT4均低于对照组,TSH高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者甲状腺体积均显著小于治疗前(P<0.05);观察组甲状腺体积明显小于对照组[(7.83±1.15) mm^2vs(14.75±2.16) mm^2],差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后各中医证候积分均显著降低(P<0.05),观察组心悸、汗多、恶热、善食易饥等积分均显著低于对照组,差异均有统计学意义(P<0.05)。观察组有效率明显高于对照组[95.56%(43/45)vs 71.11%(32/45)],差异有统计学意义(P<0.05)。观察组恶心呕吐、白细胞减少、肝酶升高总发生率明显低于对照组[4.44%(2/45)vs 20.00%(9/45)],差异有统计学意义(P<0.05)。结论:黄芪酸枣仁汤治疗甲状腺功能亢进症疗效显著,可降低FT3、FT4水平,升高TSH水平,缩小甲状腺体积,降低中医证候积分,减少不良反应。Objective:To observe the effect of clinical evaluation of jaundice jujube decoction on hyperthyroidism on thyroid volume.Methods:90 patients with hyperthyroidism were randomly divided into observation group(n=45) and control group(n=45).According to the severity of the disease,the control group received 30-60 mg of methimazole per day.The observation group was treated with Huangqi Suanzaoren Decoction on the basis of the control group.Both groups of patients were treated continuously for 8 weeks.The serum thyroxine,thyroid volume and TCM syndrome scores of the two groups were compared before and after treatment,and the clinical effects and adverse reactions during the treatment were compared between the two groups.Results:After treatment,serum free triiodothyronine(FT3) and free thyroxine(FT4) were significantly decreased in both groups,and thyroid-stimulating hormone(TSH) was significantly increased.There were statistical significance(P<0.05).Serum FT3 and FT4 in the observation group were lower than those in the control group,and TSH was higher than the control group,the difference was statistically significant(P<0.05).After treatment,the thyroid volume of the two groups was significantly less than that before treatment(P<0.05);the thyroid volume of the observation group was significantly smaller than that of the control group [(7.83±1.15) mm^2 vs(14.75±2.16) mm^2],the difference was statistically significant(P<0.05).Compared with before treatment,the scores of TCM syndromes in the two groups were significantly lower after treatment(P<0.05).The scores of palpitations,hyperhidrosis,dyscrasia,and hunger were significantly lower in the observation group than in the control group(P<0.05).The effective rate of the observation group was significantly higher than that of the control group [95.56%(43/45) vs 71.11%(32/45)],and the difference was statistically significant(P<0.05).The incidence of nausea and vomiting,leukopenia and elevated liver enzymes in the observation group was significantly lower than that in the

关 键 词：甲状腺功能亢进症 甲巯咪唑 黄芪酸枣仁汤 甲状腺素 甲状腺体积 中西医结合 

分 类 号：R259.82[医药卫生—中西医结合]