绝经后妇女骨关节炎合并骨质疏松三联治疗的临床观察  

Clinical observation of triple therapy for postmenopausal women with osteoarthritis and osteoporosis

作　　者：蒋建新[1] 柴益民[1] 虞申[1] 张先龙[1] JIANG Jianxin;CHAI Yimin;YU Shen;ZHANG Xianlong(Shanghai Sixth People’s Hospital, Shanghai 200233, China)

机构地区：[1]上海市第六人民医院,上海200233

出　　处：《中国骨质疏松杂志》2019年第2期236-239,245,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨绝经后妇女骨关节炎合并骨质疏松三联治疗的临床效果。方法选取2017年4月至2018年3月在我院治疗的64例绝经后骨关节炎合并骨质疏松患者进行研究,按照简单随机法将患者分为对照组、观察组,对照组予以非甾体类药物(NSAID)+玻璃酸钠治疗,观察组予以NSAID+玻璃酸钠+依降钙素治疗。比较两组患者的治疗效果及治疗前后VAS评分、Lysholm膝关节评分、WOMAC评分、腰骨密度值变化。结果对照组患者治疗有效率为78.13%,观察组治疗有效率为93.75%,观察组患者治疗有效率高于对照组(P<0.05)。两组患者治疗后骨密度高于治疗前(P<0.05);而在治疗后3个月、6个月,观察组患者骨密度高于对照组(P<0.05)。两组患者治疗后VAS评分、Lysholm膝关节评分、WOMAC评分低于治疗前(P<0.05);而在治疗后3个月、6个月,观察组患者VAS评分、Lysholm膝关节评分、WOMAC评分均低于对照组(P<0.05)。结论 NSAID、玻璃酸钠、依降钙素联合应用于绝经后妇女骨关节炎合并骨质疏松治疗,不仅可提高治疗效果,改善膝关节功能,还能提高活动度及患者生活质量,应用于临床可起到积极作用。Objective To explore the clinical effect of triple therapy for postmenopausal women with osteoarthritis and osteoporosis. Methods From April 2017 to March 2018, 64 cases of postmenopausal osteoarthritis with osteoporosis were studied in our hospital. According to the simple randomization method, the patients were divided into the control group and the observation group. The control group was treated with non-steroid drugs(NSAID) and sodium hyaluronate, and the observation group was treated with NSAID, sodium hyaluronate and calcitonin. The therapeutic effects of the two groups were compared, and the changes in VAS score, Lysholm knee score, WOMAC score and waist bone mineral density before and after treatment were compared. Results The effective rate of the control group was 78.13%, the effective rate of the observation group was 93.75%, and the effective rate of the observation group was higher than that of the control group(P<0.05). Bone mineral density of the two groups after treatment was higher than that before treatment(P<0.05), and bone mineral density of the observation group was higher than that of the control group at 3 months and 6 months after treatment(P<0.05). After treatment, the VAS score, Lysholm knee score and WOMAC score of the two groups were lower than those before treatment(P<0.05), and at 3 months and 6 months after treatment, the VAS score, the Lysholm knee score and the WOMAC score in the observation group were all lower than those of the control group(P<0.05). Conclusion The combination of NSAID, sodium hyaluronate and calcitonin in the treatment of postmenopausal women with arthritis and osteoporosis could not only improve the therapeutic effect, improve the function of the knee joint, but also improve the activity and the quality of life of the patients. It could play a positive role in the clinical application.

关 键 词：非甾体类药物 玻璃酸钠 依降钙素 骨关节炎 骨质疏松 

分 类 号：R684.3[医药卫生—骨科学]