^(99m)Tc-MDP骨扫描与DXA骨密度测定在骨质疏松症诊疗中的研究  

Radionuclide Scan and Dual Energy X-ray Absorptiometry on Evaluation of Osteoporosis Treatment

作　　者：楼菁菁 温广华 董科 胡永安 LOU Jing-jing;WEN Guang-hua;DONG ke;HU Yong-an(Department of Nuclear Medicine, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University),Jinhua 32100. P.R.C)

机构地区：[1]浙江省金华市中心医院(浙江大学金华医院)核医学科

出　　处：《中国医学计算机成像杂志》2019年第1期85-88,共4页Chinese Computed Medical Imaging

基　　金：金华市社会发展类重点项目99mTc-MDP时间-活度曲线在骨质疏松疗效监测中应用研究No.2013-3-004~~

摘　　要：目的:探讨^(99m)Tc-MDP骨显像与双能X-ray骨密度(DXA)测定在骨质疏松症诊疗中的研究。方法:收录本院50例骨质疏松症女性,年龄50～72岁(65.0±4.92)岁。阿仑膦酸钠治疗前及治疗后3、6、12、18个月分别进行^(99m)Tc-MDP全身骨显像和DXA骨密度(BMD)测量,对第1-4腰椎及股骨颈ROI计数与治疗前进行对比,进行骨代谢标准摄取率(SUV)分析,并与骨密度测定的治疗前后比较。结果:骨质疏松患者阿仑膦酸钠治疗后^(99m)Tc-MDP骨显像显示,第1～4腰椎SUV值治疗后6个月、股骨颈于治疗后12个月显著低于治疗前(P<0.05)。DXA测量显示,第1～4腰椎的BMD值于治疗后12个月、股骨颈于治疗后18个月时明显高于治疗前(P<0.05)。结论:初步研究结果显示,^(99m)Tc-MDP骨显像能准确反映骨质疏松症治疗后骨代谢的早期变化,较早于骨密度测定反映骨质疏松症的治疗疗效,为骨质疏松症疗效评价提供一种更早期、有效的监测技术。Purpose: To investigate the radionuclide imaging and dual energy X-ray absorptiometry(DXA) in evaluation of osteoporosis(OP) treatment. Methods: Fifty out-patients diagnosed as osteoporosis in our hospital,aged 50-72(65.0±4.92) year old, were enrolled. All patients were treated with alendrnate sodium 70 mg per seven days. 99 mTc-MDP SPECT bone scan and DXA were performed before and at 3 months, 6 months, 12 months and 18 months after treatment, respectively. SUV of lumbar 1-4 and femoral neck on 99 mTc-MDP bone imaging and bone mineral density(BMD) of lumbar 1-4 and femoral neck on DXA were calculated and compared. Results: 99 mTc-MDP bone imaging results showed that SUV of ROI on lumbar 1-4 and femoral neck at 6 months, ROI of femoral neck SUV at 12 months was lower than that before treatment(P<0.05). DXA results indicated that BMD value of lumbar1-4 at 12 months and femoral neck at 18 months after treatment was significantly higher than that before treatment(P<0.05). Conclusion: This preliminary study showed that 99 mTc-MDP SPECT bone scan can be used to earlier monitor the treatment response to OP. The results need more study to be further confirmed.

关 键 词：骨质疏松症 阿仑膦酸钠 DXA 99MTC-MDP骨显像 

分 类 号：R445.5[医药卫生—影像医学与核医学]