安胃疡胶囊致高血压及尿游离皮质醇升高  

Hypertension and elevated urinary free cortisol level caused by Anweiyang capsules(安胃疡胶囊)

作　　者：李月阳[1] 王妍[2] 赵宏伟[1] 张永凯[1] Li Yueyang;Wang Yan;Zhao Hongwei;Zhang Yongkai(Department of Pharmacy, First Hospital of Jinlin University, Changchun 130021, China;Department of Cadre Ward, First Hospital of Jinlin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院药学部,长春130021 [2]吉林大学第一医院干部病房,长春130021

出　　处：《药物不良反应杂志》2019年第1期62-64,共3页Adverse Drug Reactions Journal

摘　　要：1例65岁男性患者因慢性胃炎遵医嘱口服安胃疡胶囊0.4g、4次/d。用药约1个月后患者出现间断性头痛、头晕和血压升高,血压最高时达180/100mmHg(1mmHg=0.133kPa)。给予苯磺酸左旋氨氯地平片2.5mg口服、1次/d,血压控制不佳。约4个月后实验室检查发现患者尿游离皮质醇明显升高(2330nmol/24h)。考虑为安胃疡胶囊所致,停用该药,继续口服苯磺酸左旋氨氯地平片。患者血压和尿游离皮质醇水平于停用安胃疡胶囊第4天开始降低,第9天恢复正常。随访1个月,患者血压和尿游离皮质醇水平未见异常。A 65-year-old male patient received oral Anweiyang capsules 0.4 g four times daily for chronic gastritis. About 1 month after the medication, the patient developed intermittent headache, dizziness, and increased blood pressure, whose highest value was 180/100 mmHg. Levamlodipine besylate tablets 2.5 mg once daily was given orally but the patient′s blood pressure was not well controlled. About 4 months later, laboratory tests showed obviously increased free cortisol in urine (2 330 nmol/24 h), which was considered to be caused by Anweiyang capsules. Anweiyang capsules were stopped and the patient continued to take levamlodipine besylate tablets. On day 4 after the drug withdrawal, the patient′s blood pressure and urinary free cortisol began to decrease, which finally returned to normal on day 9. At 1 month of follow-up, no abnormalities were found on the blood pressure and urinary free cortisol in the patient.

关 键 词：高血压 糖皮质激素类 尿液 甘草次酸 安胃疡胶囊 

分 类 号：R286[医药卫生—中药学]