丹参的神经保护效应及毒理研究现状  

Recent advance in neuroprotection effect of salvia miltiorrhiza on central nervous system and related toxicology

作　　者：周龙云 崔学军[2] 陈旭青 姚敏[2] 刘书芬[2] 田子睿 王拥军 Zhou Longyun;Cui Xuejun;Chen Xuqing;Yao Min;Liu Shufen;Tian Zirui;Wang Yongjun(Rehabilitalion Medicine School,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Faculty of Basic Medicine,Research Institute of Spine Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shcmghai 200032,China;Department ofOtorhinolaryngology,Affiliaied Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210000,China)

机构地区：[1]上海中医药大学康复医学院,上海200032 [2]上海中医药大学附属龙华医院基础部,上海中医药大学脊柱病研究所,上海200032 [3]南京中医药大学附属医院耳鼻喉科,南京210000

出　　处：《中华神经医学杂志》2019年第2期199-206,共8页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81704096.81730107);上海市中医慢病(恶性肿瘤、骨退行性病变)临床医学中心重中之重项目(2017ZZ01010);上海中医药大学研究生“创新能力培养”专项科研项目(A1-182040209).

摘　　要：近年来,丹参及其活性成分在抗中枢神经系统急、慢性病变方面取得了较为显著的进展。丹参可通过多靶点调节机制,发挥抗神经炎症、抑制细胞凋亡、抗氧化应激、改善微循环、促神经再生等多种作用,其中抗氧化应激、"疏通"滞留代谢产物可能是其发挥神经保护效应的重要机制。笔者现基于中枢神经系统疾病的核心病理变化,论述丹参及其活性成分的神经保护效应及可能的效应机制,并梳理丹参毒理研究评价其药物安全性,以期为中枢神经系统疾病治疗中中医药临床转化提供一定参考。Recently,salvia miltiorrhiza has made a great progress in research of central nervous system(CNS)injury and neurodegeneration.Salvia miltiorrhiza and its active ingredients can exert multiple effects involving reduction of cell loss,attenuation of oxidative stress,improvement of micro-circulation and promotion of neuroregeneration,and show a protective effect on CNS diseases.Regulation of oxidative stress and removing accumulated metabolite may be the important mechanisms by which salvia miltiorrhiza exerts neuroprotective effects.This study will systematically discuss the pharmacological effects and possible mechanisms of salvia miltiorrhiza based on the core pathological changes in CSN diseases,and evaluate its drug safety through combing the related toxicology researches to provide a reference for clinical transformation of Chinese medicine in threatment of CNS diseases.

关 键 词：丹参 活性成分 神经保护 毒理学 

分 类 号：R285[医药卫生—中药学]