老年患者药物个体化治疗的基因多态性研究进展  

Effect of Genetic Polymorphism on Individualized Drug Therapy in Older Patients

作　　者：任佳君[1] 武军铎[1] 王珺楠[1] 侯国强[2] Ren Jiajun;Wu Junduo;Wang Junnan;Hou Guoqiang(Department of Cardiology,the Second Hospital,Jilin University,Changchun 130041,China;Department of Radiology,the Second Hospital,Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院心内科,长春130041 [2]吉林大学第二医院放射线科,长春130041

出　　处：《国际老年医学杂志》2019年第1期51-54,共4页International Journal of Geriatrics

基　　金：吉林省科技厅基金项目(20170204032YY)

摘　　要：越来越多的临床事件证明,同一种药物在治疗不同个体的同种疾病过程中,其临床疗效以及毒副作用具有很大的差异性,尤其对于老年患者而言,其对药物的敏感性及耐受性差异更加明显。大量研究发现这种差异性与患者的年龄、性别、种族、环境、所治疗疾病的性质及严重程度,伴随治疗,药物相互作用和伴随疾病情况相关,但药物代谢方面的遗传差异性以及药物治疗靶点的遗传多态性可能对许多药物的疗效和毒性产生更大的影响。因此,对于患者尤其是老年患者而言,制定药物个体化治疗方案是必要的,也是可行的,本文对此做一综述。More and more clinical events have proved that there are individual differences in drug response and side effects.The differences in drug sensitivity and tolerance are more obvious in older patients.Numerous studies have found that the differences associate with patient's age, gender, race, the nature and severity of disease and drugs interactions.However, the genetic differences in drug metabolism and genetic polymorphisms in drug therapeutic targets may have a greater impact on the efficacy and toxicity of drugs.Therefore,it is necessary and feasible for patients to formulate individualized drug treatment programs.The paper will review the effects of genetic polymorphism on drug response.

关 键 词：老年患者 基因多态性 药物效应 药物抵抗 药物不良反应 药物基因组学 

分 类 号：R592[医药卫生—老年医学]