巨细胞病毒感染对细胞线粒体结构和功能影响的研究进展  

Effects of cytomegalovirus infection on structure and function of mitochondria

作　　者：张新艳 方峰[1] Zhang Xinyan;Fang Feng(Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《中华实验和临床病毒学杂志》2019年第1期103-107,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金(81271807)。

摘　　要：巨细胞病毒(cytomegalovirus, CMV)是一种广泛存在于自然界的机会致病性病毒,其中人巨细胞病毒(human cytomegalovirus, HCMV)感染在免疫缺陷和免疫低下患者可能导致严重后果,且先天性HCMV感染是导致新生儿畸形的常见原因,可引起儿童神经发育异常。线粒体不仅是进行有氧呼吸的主要场所,同时在调控细胞生长和细胞周期方面具有重要作用,CMV感染会破坏线粒体结构,进而影响内质网-线粒体之间相关的膜状结构(mitochondria-associated membrane, MAM)和线粒体自身功能的发挥,现就CMV感染对线粒体结构和功能影响及其机制的研究进展进行综述,揭示线粒体功能紊乱在CMV感染对机体损伤中的作用。Cytomegalovirus (CMV) is a kind of common opportunistic pathogenic virus in nature.Infections with human cytomegalovirus (HCMV) always lead to serious consequences among immunodeficiency and immunocompromised individuals.And congenital HCMV infection is the most common cause of newborn malformation which result in neurodevelopmental abnormalities in children.Mitochondria are not only the leading sites of aerobic respiration,but also play important roles in regulating cell growth and cycle.Infection with cytomegalovirus will disrupt the structure of mitochondria and affect the function of mitochondria-associated membrane (MAM).This review summarized the progress about the effects of CMV infection on the structure and function of mitochondria and reveal the role of mitochondria in CMV infection on body damage.

关 键 词：巨细胞病毒 线粒体 细胞凋亡 能量代谢 

分 类 号：R373[医药卫生—病原生物学]