组织工程皮肤中感觉神经再生的研究进展  

Advances in the research of sensory nerve regeneration in tissue engineering skin

作　　者：朱志康 吴攀[1] 王新刚[1] 韩春茂[1] Zhu Zhikang;Wu Pan;Wang Xingang;Han Chunmao(Department of Burns,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院烧伤科,杭州310009

出　　处：《中华烧伤杂志》2019年第3期237-240,共4页Chinese Journal of Burns

基　　金：国家重点研发计划(2016YFC1100800);国家自然科学基金(81772069).

摘　　要：严重的皮肤损伤不仅会造成大量的组织缺损,还会导致各种感觉功能丧失。组织工程皮肤为创面高质量修复提供了新途径,但在感觉功能恢复方面仍存在诸多问题,如痛觉、触觉、温度觉的异常甚至丧失。因此,在应用组织工程皮肤促进创面愈合的同时,感觉神经的再生和功能恢复越来越受到关注。本文介绍了皮肤感觉神经的种类、分布、再生及其影响因素,并从组织工程皮肤的真皮支架、种子细胞、神经营养因子等方面探讨促进感觉神经再生的策略。Severe skin damage not only causes a mass of tissue defect, but also leads to the loss of various sensory functions. Tissue engineering skin provides a new way for high-quality wound repair, while there are still many problems in the recovery of sensory function, such as abnormality or loss of sensation of pain, touch, and temperature. Therefore, when tissue engineering skin is used to promote wound healing, regeneration and functional recovery of sensory nerve have attracted more and more attention. This article introduces the kind, distribution, regeneration, and factors influencing regeneration of sensory nerve in skin, and explores strategies in promoting regeneration of sensory nerve from dermal scaffold, seed cell, and neurturin of tissue engineering skin.

关 键 词：组织工程 皮肤 神经再生 神经营养因子 毛囊 真皮支架 

分 类 号：R622[医药卫生—整形外科]