男性低雄激素血症睾酮补充治疗的困境及其原因分析  

The dilemma of testosterone supplementation therapy for male testosterone deficiency and its possible causes

作　　者：刘伟[1] 李圣贤[1] Liu Wei;Li Shengxian(Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China)

机构地区：[1]上海交通大学医学院附属仁济医院内分泌代谢科,200127

出　　处：《中华内分泌代谢杂志》2019年第2期93-98,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81471029、81270875、81471424).

摘　　要：随着人均寿命的延长和人们对生活质量要求的提高,睾酮作为蛋白同化激素,不但能够改善肌肉和骨骼健康,还能提高精力和性能力,在国外的中老年人群,尤其在迟发型性腺功能减退(LOH)的患者中曾被广泛使用。但随着多个临床研究发现睾酮补充治疗增加心血管疾病等的风险,睾酮的使用直线下降,导致部分需要睾酮治疗的患者得不到及时的治疗。本文综合目前的临床研究结果,就睾酮补充治疗的利弊及所处的困境作一简介。Due to prolonged life expectancy, people′s requirements for quality of life are also increasing. As a protein anabolic hormone, testosterone not only improves muscle and bone health, but also improves energy and sexual function. It is widely used in middle-aged and elderly people, especially in patients with delayed-onset hypogonadism(LOH). However, as several clinical studies have found that testosterone supplementation increases cardiovascular risk, the use of testosterone decreased sharply, and some patients who require testosterone therapy thus do not receive treatment timely. This article summarizes the current clinical research results and analyzes the dilemma of testosterone supplementation therapy.

关 键 词：性腺功能减退症 睾酮 替代治疗 迟发型性腺功能减退症 心血管风险 

分 类 号：R588[医药卫生—内分泌]