慢性乙型肝炎患者血清HBV-DNA与HBeAg及ALT水平的相关性分析及临床意义  

Correlation analysis and clinical significance of serum HBV-DNA, HBeAg and ALT levels in patients with chronic hepatitis B

作　　者：林静[1] 杨洁飞[1] LIN Jing;YANG Jie-fei(Department of Clinical laboratory, Foshan First People's Hospital. Guangdong Foshan 528000)

机构地区：[1]佛山市第一人民医院检验科,广东佛山528000

出　　处：《医学检验与临床》2018年第12期30-32,共3页Medical Laboratory Science and Clinics

摘　　要：目的:探讨慢性乙型肝炎患者血清HBV-DNA 与HBeAg及ALT水平的相关性分析及临床意义.方法:选择2015年10月~2017年10月期间就诊于本院的慢性乙型肝炎患者268例,检测HBV-DNA、 HBeAg、 ALT水平,并采用Spearman相关性分析进行相关性分析.结果:以HBV-DNA水平作为因变量分析与HBeAg水平相关性,分析结果表明相关系数r=0.325, P=0.021.以HBV-DNA水平作为因变量分析与ALT水平相关性,分析结果表明相关系数r=0.417, P=0.018.结论: HBV-DNA与HBeAg、 ALT水平均呈低度相关,建议临床联合多指标检测以确定患者体内病毒复制情况和跟踪病情进展.Objective: To investigate the correlation between serum HBV-DNA, HBeAg and ALT levels in patients with chronic hepatitis B and its clinical significance. Methods: 268 patients with chronic hepatitis B in our hospital were selected. The levels of HBV-DNA,HBeAg and ALT were measured and their correlation was analyzed by Spearman correlation analysis. Results: Using HBV DNA level as the dependent variable analysis, Spearman correlation analysis showed that the correlation coefficient with HBeAg level was r=0.325, P=0.021, and that the correlation coefficient with ALT was r=0.417, P=0.018. Conclusion: HBV-DNA is associated with low levels of HBeAg and ALT. It is recommended that clinical combined multi-indicators should be used to determine viral replication and track progression in patients.

关 键 词：慢性乙型肝炎 乙肝病毒核酸 乙肝病毒E抗原 ALT 

分 类 号：R512.62[医药卫生—内科学]