鼻上皮细胞DNA甲基化水平对于哮喘的诊断与治疗的意义  

Significance of DNA methylation in nasal epithelial cells in the diagnosis and treatment of asthma

作　　者：张黎莎 钱粉红[1] Zhang Lisha;Qian Fenhong(Depurtment of Respiratory Medicine,the Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院呼吸内科,镇江212000

出　　处：《国际呼吸杂志》2019年第5期382-386,共5页International Journal of Respiration

基　　金：国家自然科学基金项目(81370119);镇江市科技支撑计划(SH2015044).

摘　　要：哮喘是一种以气道高反应性特点的慢性呼吸道疾病,近年来其患病率呈逐年升高趋势,目前认为其病因可能与基因及环境刺激有关。对于哮喘患者最有效的治疗措施是糖皮质激素,然而由于哮喘患者分型和症状不完全相同,给哮喘的诊断和治疗带来困难。本综述选取鼻上皮细胞作为生物学样本,对甲基化水平与哮喘的诊断和治疗的关系进行概述。Asthma is a chronic respiratory diseases characterized by airway hyperresponsiveness.Asthma prevalence has been on the increase,and the most reliable pathogeny of asthma is thought to be genetic change and environmental stimulation.Nowadays,corticosteroids are widely used to treat asthma.However,asthma is heterogeneous,which brings difficulties in the diagnosis and treatment of asthma.We chose nasal epithelium as a proxy tissue to sum up the connection between nasal DNA methylation and the diagnosis and treatment of asthma.

关 键 词：哮喘 鼻上皮细胞 甲基化 诊断 治疗 

分 类 号：R562.25[医药卫生—呼吸系统]