超声测量肺动脉内径及McGoon指数评估法洛四联症胎儿肺发育的研究  

Fetal Pulmonary Artery Changes in Patients with Tetralogy of Fallot:Quantitative Ultrasound Analysis

作　　者：郭勇[1] 刘晓伟[1] 刘文旭[1] 张烨[1] 孙琳[1] 谷孝艳[1] 何怡华[1] Guo Yong;Liu Xiaowei;Liu Wenxu;Zhang Ye;Sun Lin;Gu Xiaoyan;He Yihua(Department of Ultrasound,Anzhen Hospital of Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院超声心动二部,北京市100029

出　　处：《中国超声医学杂志》2019年第3期256-259,共4页Chinese Journal of Ultrasound in Medicine

基　　金："十三五"国家重点研发计划项目(No.2018YFC1002300);胎儿心脏病母胎医学研究北京市重点实验室(No.BZ0308);首都卫生发展科研专项经费资助(No.2016-1-2061)

摘　　要：目的应用二维超声测量肺动脉内径及McGoon指数评价法洛四联症(TOF)对胎儿肺发育的影响。方法以41例TOF胎儿为研究对象,110例正常胎儿为对照组,二维超声测量肺动脉内径及McGoon指数,三维超声测量肺体积(FLV),对比分析TOF胎儿肺动脉变化,并将肺动脉参数与FLV进行相关回归分析。结果 (1)TOF胎儿肺动脉McGoon指数较正常胎儿明显减低(P<0.05)。(2)矫正胎儿GA、EFW、CTR、DA影响因素后,左右肺动脉内径之和(RPA+LPA)与FLV呈显著正相关关系(P<0.05)。结论 TOF胎儿McGoon指数明显低于正常胎儿,提示此类先心病在胎儿时期可能已经对肺动脉发育产生一定不良影响。RPA+LPA与胎儿FLV呈明显线性正相关,二维超声测量左右肺动脉一定程度上可反映胎儿肺发育情况。Objective The objective of this study was to quantify fetal pulmonary vascular parameters in TOF cases.Methods 41 fetuses with TOF and 110 healthy fetuses were enrolled in the study.Diameters of right pulmonary artery and left pulmonary artery(RPA+LPA)and MGI were estimated by 2 D-ultrasound.Fetal lung volume(FLV)was estimated using 3 D-ultrasound.Results McGoon in TOF group was significantly reduced than in control group,and RPA+LPA was associated with FLV both in the TOF and control groups(all P<0.05).Conclusions MGI values in fetuses with TOF tended to be decreased.We concluded that TOF might delay fetal pulmonary vascular development.FLV was associated with RPA+LPA,and RPA+LPA could be used as an alternative to FLV for assessing fetal lung development.

关 键 词：法洛四联症 肺动脉 肺体积 McGoon指数 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]