Fabrication of shish-kebab-structured carbon nanotube/poly(ε-caprolactone) composite nanofibers for potential tissue engineering applications  

作　　者：Tong Wu Xin Chen Jin Sha Yi-Yan Peng Yu-Lu Ma Lin-Sheng Xie Lih-Sheng Turng 

机构地区：[1]Engineering Center of Efficient Green Process Equipment and Energy Conservation, Ministry of Education, East China University of Science and Technology [2]School of Mechanical and Power Engineering, East China University of Science and Technology [3]Wisconsin Institute for Discovery, University of Wisconsin-Madison

出　　处：《Rare Metals》2019年第1期64-72,共9页稀有金属（英文版）

基　　金：financially supported by the Fundamental Research Funds for the Central Universities (No. 22A201514030);China Postdoctoral Science Foundation (No. 2015M571504);the National Natural Science Foundation of China (Nos. 51503065 and 51273065);the Wisconsin Institute for Discovery in University of Wisconsin-Madison;China Scholarship Council

摘　　要：The electrospinning process was applied to fabricate the nanofibers of biodegradable poly(ε-caprolactone)(PCL) in which different contents of multiwalled carbon nanotubes(MWCNTs) were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts(MG-63 cells). The carbon nanotube(CNT) concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.The electrospinning process was applied to fabricate the nanofibers of biodegradable poly(ε-caprolactone)(PCL) in which different contents of multiwalled carbon nanotubes(MWCNTs) were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts(MG-63 cells). The carbon nanotube(CNT) concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.

关 键 词：Carbon NANOTUBES Poly(ε-caprolactone) ELECTROSPINNING SHISH-KEBAB structure Tissue engineering 

分 类 号：TQ342.87[化学工程—化纤工业]