茵芍二黄汤治疗原发性胆汁性胆管炎及对Treg/TGF-β轴调节的初步研究  

A Preliminary Study On The Treatment Of Primary Biliary Cholangitis And Treg/TGF-β Axis Regulation By Yin Shao Er Huang Recipe

作　　者：刘全忠[1] 闫乐[1] 赵文霞[1] LIU Quan-zhong;YAN Le;ZHAO Wen-xia(The department of digestive, The First Affiliated Hospital of Henan University of Traditional ChineseMedicine (Zhengzhou Henan ,450000) China)

机构地区：[1]河南中医药大学第一附属医院脾胃肝胆病科,河南郑州450000

出　　处：《中西医结合肝病杂志》2019年第1期10-12,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河南省中医药科学研究专项课题(No.2016z2053)

摘　　要：目的:观察茵芍二黄汤联合牛磺熊去氧胆酸胶囊治疗原发性胆汁性胆管炎(PBC)的临床疗效及其对外周血中Treg细胞及转化生长因子-β(TGF-β)、白介素10(IL-10)的影响。方法:60例PBC患者,参照数字法随机分为对照组29例及治疗组31例。对照组患者给予牛磺熊去氧胆酸胶囊1粒/次,3次/d;治疗组患者在对照组用药基础上加用茵芍二黄汤,1剂/d,煎煮后早晚分服,两组患者治疗疗程均为24周。观察两组患者中医临床症状积分,治疗前后血清TBil、ALT、AST、ALP、GGT情况,比较两组患者治疗前后临床疗效;检测两组患者治疗前后外周血中Treg细胞及血清TGF-β、IL-10水平。结果:经治疗两组患者中医症状积分、肝功能均明显改善(P<0.05),治疗组优于对照组(P<0.05)。两组患者治疗后外周血中Treg细胞及血清中TGF-β、IL-10明显增多(P<0.05),治疗组高于对照组(P<0.05)。结论:茵芍二黄汤联合牛磺熊去氧胆酸胶囊治疗PBC可显著改善患者临床症状及肝功能,通过调节外周血Treg细胞及其表达的特异细胞因子TGF-β、IL-10水平是其治疗该病可能的机制之一。Objective:To observe the clinical efficacy of Yin Shao Er Huang Recipe and Tauroursodeoxycholic Acid Capsules on the treatment of PBC and the effect of TGF-β and IL-10 in peripheral blood.Methods:Sixty cases of PBC,according to the numerical method,were randomly divided into control group of 29 cases and treatment group of 31 cases.The control group was given 15 mg/(kg/d) and 3 times/day of Tauroursodeoxycholic acid capsules;On the basis of the control group,the treatment group was supplemented with Yin Shao Er Huang Recipe,1 dose/day,After the decoction is done,both groups were treated for 24 weeks.Observe the clinical symptom integral of TCM in two groups,before and after of treatment serum TBIL,ALT,AST,ALP and GGT.The clinical efficacy of the two groups were compared before and after treatment.The levels of Treg cells and serum TGF-β and IL-10 were detected in peripheral blood before and after treatment in both groups.Results:The symptom score and liver function of the both groups were significantly improved(P<0.05),And the treatment group was superior to the control group(P<0.05).The TGF-β and IL-10 of Treg cells and serum in peripheral blood were significantly increased after treatment(P<0.05),And the treatment group was higher than the control group(P<0.05).Conclusion:Yin Shao Er Huang Recipe and Tauroursodeoxycholic Acid Capsules could significantly improve the clinical symptoms and liver function of PBC patients.It is one of the possible mechanisms for the treatment of peripheral blood Treg cells and the specific cytokines TGF-β and IL-10.

关 键 词：茵芍二黄汤 牛磺熊去氧胆酸胶囊 原发性胆汁性肝硬化 Treg/TGF-β轴 

分 类 号：R259[医药卫生—中西医结合]