国产CalliSpheres载药微球栓塞治疗不可切除肝癌17例分析  

Interventional chemoembolization with drug-eluting microspheres of domestic CalliSpheres for the treatment of unresectable hepatocellul-ar carcinomas:preliminary results in 17 cases

作　　者：葛世堂 张希全[1] 窦树彬 郭锋[1] 陆圣月 王鑫[1] GE Shi-tang;ZHANG Xi-quan;DOU Shu-hing(Department of Interventional Vascular,the 148th Hospital of Chinese People's LiberationArmy( Zibo Shandong,255300) China)

机构地区：[1]中国人民解放军第960医院全军腔内介入诊疗中心,山东淄博255300

出　　处：《中西医结合肝病杂志》2019年第1期40-43,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨国产CalliSpheres载药微球栓塞治疗不可切除肝癌的安全性及临床疗效。方法:回顾性分析2016年11月至2017年12月在本中心接受CalliSpheres载药微球栓塞治疗的17例不可切除肝癌患者临床资料,并依据国际通用的改良实体瘤疗效评价标准(mRECIST)评价治疗效果。结果:17例患者均成功完成手术,技术成功率100%。术后1周患者AST、ALT、肌酐、血红蛋白、白细胞及血小板数值与术前比较,差异无统计学意义(均P>0.05);17例患者随访6～12个月,中位随访时间为9个月。依据mRECIST标准,术后3、6个月时疾病缓解率(CR+PR)分别为76.5%、70.6%;疾病控制率(CR+PR+SD)分别为94.1%、82.4%。所有患者均未出现肝功能衰竭、胆囊炎、胆汁瘤及消化道出血等严重并发症。结论:国产CalliSpheres载药微球栓塞治疗不可切除肝癌是安全可行的,近期临床疗效较好,值得临床推广应用。Objective:To investigate the safety and clinical effect of interventional chemoembolization with drug-eluting microspheres of domestic CalliSpheres for the treatment of unresectable hepatocellular carcinomas.Methods:The clinical data of 17 patients with unresectable hepatocellular carcinomas,admitted to our hospital from November 2016 to December 2017,were retrospectively analyzed.A total of 17 patients with unresectable hepatocellular carcinomas underwent transcatheter arterial chemoembolization with drug-eluting microspheres of domestic CalliSpheres,the results were evaluated with modified response evaluation criteria in solid tumors mRECIST.Results:The procedure was all successful in 17 patients,technical success rate was 100%.There was no significant difference in AST,ALT,creatinine,hemoglobin,white blood cell count and Platelet count existed between preoperative data and postoperative ones(P>0.05).All the 17 cases were followed up for 6 to 12 months,with a mean of 9 months.According to mRECIST,the disease remission rate(CR+PR) were 76.5% and 70.6% respectively,the disease control rate(CR+PR+SD) were 94.1% and 82.4% respectively.No serious complications,such as hepatic failure,cholecystitis,intrahepatic biloma and gastrointestinal bleeding,etc.occurred in all patients.Conclusion:The use of domestic CalliSpheres,as a drug-eluting microspheres for the treatment of unresectable hepatocellular carcinomas is safe and effective with short-term efficacy,which is worthy of clinical popularization and application.

关 键 词：国产CalliSpheres载药微球 肝癌 肝动脉化疗栓塞术 临床疗效 

分 类 号：R735.7[医药卫生—肿瘤]