孕晚期抑郁与婴儿气质发育关联的随访研究  

A follow-up study of the association between depression in late pregnancy and infant temperament development

作　　者：王小燕 焦雪纯[1] 解钧 刘洋 余宛琪 朱鹏 WANG Xiao-yan;JIAO Xue-chun;XIE Jun;LIU Yang;YU Wan-qi;ZHU Peng(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei Anhui 230032,China)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,安徽合肥230032 [2]安徽医科大学第一附属医院高新院区新生儿科,安徽合肥230031 [3]人口健康与优生安徽省重点实验室,安徽合肥230032

出　　处：《现代预防医学》2019年第6期1011-1015,共5页Modern Preventive Medicine

基　　金：国家自然科学基金面上项目(编号:818726318;1472991);安徽省高校优秀青年人才基金重点项目(编号:gxyqZD2018025);国家级大学生创新训练项目(编号:201710366029)

摘　　要：目的探讨孕32～36周高水平抑郁情绪对婴儿气质发育的影响。方法以741名孕32～36周进行产前检查的孕妇为研究对象,采用自制问卷获得人口统计学信息,并使用流调中心用抑郁自评量表(CES-D)进行抑郁情绪筛查。产妇分娩后收集分娩结局资料。在产后6个月时进行家庭访视,应用婴儿气质量表评估婴儿气质发育。结果抑郁组母亲中,低年龄、低教育水平、分娩女婴和产后人工喂养比例均高于无抑郁组。控制潜在混杂因素后,抑郁组婴儿6月龄时,适应性(差值=0.33, 95%CI:0.16～0.51, P=0.001)、情绪(差值=0.31, 95%CI:0.006～0.614, P=0.047)、注意分散(差值=0.29, 95%CI:0.13～0.45, P=0.002)和反应阈(差值=0.28, 95%CI:0.02～0.54, P=0.028)4个维度的得分均高于无抑郁组母亲的婴儿。结论孕晚期抑郁情绪可能与婴儿气质发育间存在独立关联。Objective The aim of this study was to investigate the effect of high-level depression in 32 to 36 weeks of pregnancy on the development of infants'temperament.Methods A total of 471 pregnant women who were pregnant for 32 to 36 weeks were enrolled in the study.The self-made questionnaire was used to obtain the demographic information,and the Depression Self-Rating Scale(CES-D)was used to conduct depression screening.Childbirth outcomes were collected after childbirth.Breastfeeding and infant temperament questionnaires were conducted by telephone follow-up at 6 months postpartum.Results The proportions of low age,low education,childbirth,and artificial feeding at 4 months postpartum were significantly higher in the depressed group than those in the non-depression group.After controlling for potential confounding factors,the infants of the mothers in the depressed group had significantly higher scores in the dimensions of temperament,mood,distraction,and response thresholds at 6 months than infants without mothers with depression.The differences were statistically significant(P<0.05).Conclusion High-level depression in the third trimester can independently affect the development of the infant's temperament.

关 键 词：妊娠 抑郁 婴儿 气质 随访研究 

分 类 号：R173[医药卫生—妇幼卫生保健]