同种异体移植炎症因子1研究进展  

Research of allograft inflammatory factor 1

作　　者：鲍维佳 郝丽荣[1] BAO Weijia;HAO Lirong(The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China)

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150000

出　　处：《肾脏病与透析肾移植杂志》2019年第1期91-94,23,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金(81570638)

摘　　要：同种异体移植炎症因子1(allograft inflammatory factor 1,AIF-1)是从慢性排斥的心脏移植物中克隆的一种高度保守的炎症反应支架蛋白,通过调节细胞因子、趋化因子和诱导型一氧化氮合酶等炎症介质的表达参与炎症反应,是巨噬细胞活化的标志物。AIF-1具有广泛的生物学特性,参与移植排斥反应、自身免疫性疾病、肿瘤、血管病变、生殖系统疾病和中枢神经疾病的发生及发展,在多种疾病中起重要作用。Allograft inflammatory factor 1(AIF-1)is a highly conservative inflammation scaffold protein cloned from chronic rejection of cardiac grafts.By adjusting the cytokines,chemokines and inducible nitric oxide synthase expression of inflammatory mediators involved in inflammation,it is considered to be a macrophage activation marker. AIF-1 has a wide range of biological characteristics,and plays an important role in occurrence and development of transplant rejection,autoimmune diseases,tumor,vasculopathy,reproductive system diseases and central nervous diseases.

关 键 词：同种异体移植炎症因子1 炎症 移植排斥 自身免疫 血管病变 

分 类 号：R617[医药卫生—外科学]