儿童支气管哮喘易感基因相关研究进展  

Advances in the study of susceptibility genes to bronchial asthma in children

作　　者：鲍一笑 白沙沙 Bao Yixiao;Bai Shasha(Department of Pediatrics,Children′s National Medical Center,Shanghai Children′s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai Pubin Children′s Hospital,Shanghai 200127,China;Department of Pediatrics,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)

机构地区：[1]国家儿童医学中心,上海交通大学医学院附属上海儿童医学中心,上海浦滨儿童医院儿科,上海200127 [2]上海交通大学医学院附属新华医院儿科,200092

出　　处：《中华实用儿科临床杂志》2019年第4期241-244,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：支气管哮喘(简称哮喘)是由众多基因与环境因素相互作用的复杂异质性疾病。随着对哮喘基因研究的深入,一些新的儿童哮喘易感基因不断被发现,基因与环境交互作用对哮喘的影响被广为关注,不同基因位点组合对儿童哮喘的发病具有预测效应。现就哮喘易感基因的研究历史、近年来新发现的儿童哮喘易感基因以及不同基因位点组合对儿童哮喘的预测效应等方面进行介绍。Bronchial asthma(asthma for short)is a complex heterogeneous disease,which is caused by multiple gene-environmental interaction.With the progress of asthma gene research,some new childhood asthma susceptibility genes have been found,and the influence of genes interaction with environment on asthma is being widely attended;different genetic loci combination can predict the onset of childhood asthma.Now,the history of asthma gene research and some newly discovered childhood asthma susceptibility genes in recent years and different genetic loci combination prediction effect and so on were introduced.

关 键 词：支气管哮喘 易感基因 全基因组关联分析研究 模型 

分 类 号：R725.6[医药卫生—儿科]