某医院碳青霉烯类抗菌药物使用情况分析与用药合理性评估  

Analysis on use of carbapenems and evaluation of the medication rationality in a hospital

作　　者：方莎莎 陈安妮[1] 李悦悦[1] 王琳召 胡云英 张国庆[1] 王慧[1] FANG Sha-sha;CHEN An-ni;LI Yue-yue;WANG Lin-zhao;HU Yun-ying;ZHANG Guo-qing;WANG Hui(Department of Pharmacy,Eastern Hepatobiliary Surgery Hospital,Naval Medical University (Second Military Medical University),Shanghai 200438,China)

机构地区：[1]海军军医大学(第二军医大学)东方肝胆外科医院药材科,上海200438

出　　处：《第二军医大学学报》2019年第3期341-345,共5页Academic Journal of Second Military Medical University

基　　金：上海医院药学科研项目(2014-YY-02-12)~~

摘　　要：目的分析某医院2016年碳青霉烯类抗菌药物使用情况,以指导抗菌药物临床合理使用。方法抽取该院2016年所有使用碳青霉烯类抗菌药物患者的病历资料,对抗菌药物使用情况、感染类型、病原学检查情况进行汇总统计,并对抗菌药物使用合理性进行评估,对使用不适宜问题进行分类。结果共抽取383例患者的病历资料,女137例(35.78%)、男246例(64.22%),平均年龄为(59±12)岁,中位年龄为61岁。总送检率为95.30%(365/383);按药物敏感试验结果选择用药者258例(67.36%);亚胺培南西司他丁钠和比阿培南的药物利用指数分别是1.29和0.76;用药不适宜病历共60份(15.67%)。结论该医院2016年碳青霉烯类抗菌药物临床使用仍存在不合理情况。开展碳青霉烯类抗菌药物临床专项点评有利于掌握临床使用情况,发现存在的典型问题,为制定合理用药干预措施提供参考。Objective To analyze the use of carbapenems in a hospital in 2016, so as to provide evidence for rational use of antibiotics. Methods The medical records of all patients treated with carbapenems in 2016 were collected. The use of antimicrobial agents, types of infections and etiological examinations were investigated. The medication rationality of antibiotics was evaluated, and the inappropriate problems were classified. Results A total of 383 cases were extracted, including 137 (35.78%) females and 246 (64.22%) males, with an average age of (59±12) years and a median age of 61 years. The total inspection rate was 95.30%(365/383). A total of 258 cases (67.36%) received the medicine according to the drug sensitivity results. The drug utilization indexes of imipenem/cilastatin sodium and biapenem were 1.29 and 0.76, respectively. There were 60 cases (15.67%) of irrational use of carbapenems. Conclusion There is still unreasonable clinical use of carbapenems in the hospital in 2016. The rationality evaluation of carbapenems use is conducive to understanding the clinical use and finding the typical problems, so as to provide reference for rational drug intervention.

关 键 词：碳青霉烯类 处方点评 合理用药 微生物敏感性试验 

分 类 号：R978.11[医药卫生—药品]