ABO血型因素对阿司匹林抗凝效果的影响  

Effect of ABO blood group factor on anticoagulation with aspirin

作　　者：乌云格日勒 于建设[1] 温再和[1] Wuyun Gerile;Yu Jianshe;Wen Zaihe(Department of Anesthesiology,Affiliated Hospital of Inner Mongolia Medical University,Huhhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院麻醉科,呼和浩特市010050 [2]内蒙古自治区人民医院麻醉科

出　　处：《中华麻醉学杂志》2018年第12期1493-1495,共3页Chinese Journal of Anesthesiology

基　　金：内蒙古自然科学基金(2010MS1142).

摘　　要：目的评价ABO血型因素对阿司匹林抗凝效果的影响。方法近期未服用阿司匹林患者73例,性别不限,年龄45~70岁,根据ABO血型分为4组:A型血组(A组,n=18)、B型血组(B组,n=20)、AB型血组(AB组,n=15)和O型血组(O组,n=20)。口服阿司匹林100mg/d,持续2周。于用药前(T1)及用药2周后(T2)空腹采集外周静脉血样测定APTT、TT、PT、Fib、Plt和血小板聚集率。结果4组T1,2时Plt、T1时血小板聚集率比较差异无统计学意义(P>0.05)。与A组、B组、AB组比较,O组T1时PT、APTT、TT延长,Fib降低,T2时血小板聚集率降低(P<0.05)。与T1时比较,T2时4组PT、APTT、TT、Fib和Plt差异无统计学意义(P>0.05),血小板聚集率降低(P<0.05)。结论ABO血型因素与阿司匹林抗凝效果的个体差异有关,A型、B型、AB型血患者对阿司匹林抗凝效果敏感性一致,O型血患者更敏感。Objective To evaluate the effect of ABO blood group factor on anticoagulation with aspirin. Methods Seventy-three patients of both sexes, aged 45-70 yr, who did not take aspirin recently, were divided into 4 groups according to the blood group: blood group A group (group A, n=18), blood group B group (group B, n=20), blood group AB group (group AB, n=15), and blood group O group (group O, n=20). Aspirin 100 mg/d was taken orally for 2 weeks.Fasting blood samples were taken from the peripheral vein before administration (T1) and at 2 weeks after administration (T2) for measurement of activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), fibrinogen (Fib), platelet count (Plt) and platelet aggregation rate. Results There was no significant difference in Plt at T1, 2 or platelet aggregation rate at T1 among the four groups (P>0.05). Compared with A, B and AB groups, PT, APTT and TT were significantly prolonged and Fib was decreased at T1, and platelet aggregation rate was decreased at T2 in group O (P<0.05). Compared with the baseline at T1, no significant change was found in PT, APTT, TT, Fib or Plt at T2 (P>0.05), and platelet aggregation rate was significantly decreased at T2 in the four groups (P<0.05). Conclusion ABO blood group factor is related to the individual variation in anticoagulation with aspirin, patients of A, B and AB blood group have the same sensitivity to anticoagulation with aspirin, and patients of O blood group are more sensitive to anticoagulation with aspirin.

关 键 词：ABO血型系统 阿司匹林 血小板聚集 

分 类 号：R969[医药卫生—药理学]