中药调节信号转导通路诱导肿瘤细胞自噬的实验研究进展  

Experimental research progress of Chinese medicine in inducing tumor cell autophagy through regulating related signaling pathways

作　　者：杨柳[1,2] 朱惠蓉[2] 冯煜[2] 李琦[2] YANG Liu;ZHU Huirong;FENG Yu;LI Qi(Department of Medical Oncology, Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai 201999, China;Department of Medical Oncology, Shuguang Hospital Affiliated to Shanghai University ofTraditional Chinese Medicine, Shanghai 201203, China)

机构地区：[1]上海中医药大学附属曙光医院宝山分院肿瘤科,上海201999 [2]上海中医药大学附属曙光医院肿瘤科,上海201203

出　　处：《上海中医药大学学报》2019年第2期92-96,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金重点项目(81830120);上海市科委科研基金项目(16401970500;16401930700);上海市公共卫生三年行动计划项目(GWIV-28);上海市中医药事业发展三年行动计划项目(CCCX-2003-03;CCCX-2003-02;FWTX-4026);上海市优秀学术带头人培养计划项目(16XD1403600);上海市领军人才计划项目(2016039)

摘　　要：自噬是以细胞质内出现自噬小体为特征的细胞自我消化和吸收的过程,是影响肿瘤发生发展过程的关键因素,具有抑癌和促癌的双重调节作用,且多条信号转导通路参与调控肿瘤细胞自噬。已证实多种中药及其活性成分、中药复方具有显著的抗肿瘤作用,其机制可能与诱导肿瘤细胞自噬有关。对肿瘤细胞自噬相关的信号转导通路进行分析和总结,并从PI3K/AKT-mTOR、AMPK、MAPK、Beclin-l、Wnt/β-catenin等通路综述中药诱导自噬、抗肿瘤的分子机制。Autophagy is a process of self-digestion and absorption of cells,which characterized by autophagosomes in the cytoplasm. It is a key factor affecting the process of tumorigenesis and development. It shows the dual regulatory roles of anti-cancer and promoting cancer. Multiple signal transduction pathways involve in and regulate the autophagy of tumor cells. Various Chinese medicine and their active ingredients,as well as compound recipes,have been confirmed to have obvious anti-tumor effects,and their mechanisms may be related to inducing tumor cell autophagy. In this paper,the signal transduction pathways related to autophagy of tumor cells are analyzed and summarized,and the molecular mechanisms of Chinese medicine on inducing autophagy and anti-tumor are reviewed from PI3 K/AKT-mTOR,AMPK,MAPK,Beclin-l,Wnt/β-catenin signaling pathways.

关 键 词：肿瘤 自噬 中药 信号转导通路 综述 

分 类 号：R285[医药卫生—中药学]