类固醇激素及自体骨髓注射治疗儿童单纯性骨囊肿的有效性meta分析  

The efficacy of corticosteroids injection and autologous bone marrow injection in the treatment of simple bone cyst in children: a meta-analysis

作　　者：张戈 周荣 张圆[1] 李明[1] ZHANG Ge;ZHOU Rong;ZHANG Yuan;LI Ming(Orthopedic Center of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014 China)

机构地区：[1]重庆医科大学儿童医院骨科中心儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室,重庆400014

出　　处：《海南医学院学报》2019年第7期524-529,共6页Journal of Hainan Medical University

基　　金：国家临床重点专科建设项目[国卫办函(2013)544]~~

摘　　要：目的:通过分析国内外文献,系统评价类固醇激素及自体骨髓注射治疗儿童单纯骨囊肿的有效性。方法:系统检索Pubmed、Cochrane Library、Embase、CBM、CNKI、万方、维普等数据库中,相关类固醇激素及自体骨髓注射治疗儿童单纯骨囊肿疗效比较的文献,对纳入文献进行质量评价及数据提取,采用RevMan 5.3软件进行Meta分析的相关计算。结果:共纳入5项研究,共计246例单纯性骨囊肿患儿,其中132例接受经皮类固醇激素注射,114例接受经皮自体骨髓注射。对比经皮类固醇激素与自体骨髓注射,总体治愈率(OR=1.29,95%CI=0.57～2.88,P=0.54)、手术后病理性骨折发生率(OR=1.04,95%CI=0.47～2.30,P=0.92)、治疗后复发率(OR=3.24,95%CI=0.96～10.96,P=0.06)均无显著统计学差异。结论:经皮类固醇激素注射与自体骨髓注射治疗儿童单纯性骨囊肿疗效及安全性无显著差异,但自体骨髓注射治疗需取材于自体骨髓,可致穿刺部位疼痛,并存在感染出血等风险,且增加患者心理及经济负担。Objective: Evaluating the effectiveness of steroids and autologous bone marrow injection in the treatment of children with simple bone cysts. Methods: The literatures of Pubmed, CBM, CNKI, Wanfang Data, and VIP Database were compared in the database of corticosteroids injection and autologous bone marrow injection for the treatment of children with simple bone cysts. The literature was retrieved until June 2018. Read the abstract or full text of the literature carefully, track the references, evaluate the quality of the included literature and extract the data, and use RevMan 5.3 for Meta-analysis. Results: There were five studies were included, a total of 246 children with simple bone cysts were enrolled in the study. Of these, 132 received percutaneous steroid injection and 114 received percutaneous autologous bone marrow injection. Comparison of percutaneous steroids injection with autologous bone marrow injection, there was no significant difference in overall cure rate( OR =1.29,95% CI =0.57-2.88, P =0.54), incidence of pathological fractures after surgery( OR =1.04,95% CI =0.47-2.30, P =0.92), and recurrence rate( OR =3.24,95% CI =0.96-10.96, P =0.06). Conclusion: There was no significant difference in the efficacy of percutaneous steroid injection and autologous bone marrow injection in the treatment of children simple bone cyst.

关 键 词：单纯性骨囊肿(UBC) 类固醇激素 自体骨髓 META分析 

分 类 号：R726.8[医药卫生—儿科]