参苓白术散对慢性阻塞性肺疾病稳定期肺脾两虚患者运动耐力及氧化应激水平的影响  

Influence of Shenlingbaizhu Powder on exercise tolerance and oxidative stress in patients with chronic obstructive pulmonary disease at stable stage of lung-spleen deficiency syndrome

作　　者：胡涛[1] 马军[1] 蔡敬宙[1] 金龙伟 卫卓欣 HU Tao;MA Jun;CAI Jing-zhou;JIN Long-wei;WEI Zhuo-xin(Guangzhou First People's Hospital,Guangzhou 510180,China;Integrated Traditional Chinese and Western Medicine Hospital of Southern Medical University,Guangzhou 510310,China)

机构地区：[1]广州市第一人民医院,广东广州510180 [2]南方医科大学中西医结合医院,广东广州510310

出　　处：《时珍国医国药》2019年第1期125-127,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81704020)

摘　　要：目的观察参苓白术散对慢性阻塞性肺疾病稳定期肺脾两虚患者运动耐力及氧化应激水平的影响。方法将58例COPD稳定期患者随机分为对照组29例和治疗组29例。两组均给予常规基础治疗,治疗组在常规基础治疗上加用参苓白术散(党参、茯苓、白术、薏苡仁等)治疗,疗程均为4周,比较两组患者治疗前后的6分钟步行距离、肺功能和氧化应激水平。结果与治疗前相比,治疗组治疗后6MWD明显增加,且与对照组治疗后相比,具有明显差异(P<0.05);治疗组FEV1%和FEV1/FVC治疗后较治疗前有所改善,但无统计学意义,治疗后两组FEV1/FVC间有差异(P<0.05);两组治疗后的SOD含量较治疗前明显升高,而MDA含量显著降低,具有统计学意义(P<0.05);与对照组治疗后比较,治疗组的氧化应激水平明显减轻(P<0.05)。结论参苓白术散可提高慢性阻塞性肺疾病稳定期肺脾两虚患者运动耐力,其作用机制可能与其减轻氧化应激反应有关,具体分子生物机制有待于进一步研究。Objective Objective to observe the influence of Shenlingbaizhu Powder on exercise tolerance and oxidative stress in patients with chronic obstructive pulmonary disease at stable stage of lung-spleen deficiency syndrome.Methods 58 cases of COPD in stable stage patients,was randomly divided into control group and treatment group,each group contains 29 cases.Both were given the conventional treatments,the treatment group received Shenlingbaizhu Powder based on the basic treatments.The courses of treatment were 4 weeks.The observation indexes included 6 minutes walking distance(6 MWD),lung function and the level of oxidative stress.Results Compared to pre-treatment,there is a significant improvement of 6 MWD in treatment group.Compared to control group,6 MWD after treatment was obviously better in treatment group(P<0.05),which expressed the same in the FEV1/FVC(P<0.05).There is no difference in FEV1% and FEV1/FVC,compared to pre-treatment,although improvement was found.The levels of SOD in the two groups were significantly higher than before treatment,while the contents of MDA decreased significantly,which was statistically significant(P<0.05).Compared with the control group,the oxidative stress level decreased significantly(P<0.05).Conclusion Shenlingbaizhu Powder has good therapeutic effect on exercise tolerance of patients with chronic obstructive pulmonary disease at stable stage of lung-spleen deficiency syndrome.The mechanism may be revelant to reduction of oxidative stress.However,the specific mechanism remains to be further researched.

关 键 词：参苓白术散 慢性阻塞性肺疾病 运动耐力 氧化应激 

分 类 号：R256.1[医药卫生—中医内科学] R289.5[医药卫生—中医学]