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作 者:何莎[1] 曹春艳 郑毅[2] 宋越[2] 王静[2] He Sha;Cao Chunyan;Zheng Yi;Song Yue;Wang Jing(Department of Ultrasound, Maternal and Child Health Hospital of Hubei, Wuhan 430070, China;Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022 , China)
机构地区:[1]湖北省妇幼保健院超声诊断科,武汉430070 [2]华中科技大学同济医学院附属协和医院超声影像科分子影像湖北省重点实验室,武汉430022
出 处:《中国医师杂志》2019年第3期327-330,共4页Journal of Chinese Physician
基 金:国家自然科学基金(81771851)~~
摘 要:目的探讨慢性移植肾肾病患者的肾实质剪切波速度(SWV)和血清中转化生长因子-β1(TGF-β1)的变化及其相关性。方法选取行移植肾穿刺活检病理组织学检查确诊的慢性移植肾肾病患者60例作为病例组,按移植肾肾间质纤维化和肾小管萎缩程度,分为C1组(<25%的肾皮质受累,共20例)、C2组(25%~50%的肾皮质受累,共20例)、C3组(> 50%的肾皮质受累,共20例),同期选择肾功能正常的30例肾移植患者为对照组。应用声触诊组织量化技术检测各组移植肾肾实质SWV,并应用ELISA法检测各组血清TGF-β1水平;比较各组间的TGF-β1水平及移植肾肾实质SWV,并对二者进行相关性分析。结果 C1、C2、C3组患者移植肾肾实质SWV值和血清TGF-β1水平较对照组均明显增加,差异均有统计学意义(均P <0. 05); C3组SWV值大于C1、C2两组,C2组SWV值大于C1组,差异均有统计学意义(均P <0. 05)。C1组、C2组、C3组血清TGF-β1水平两两比较,差异均有统计学意义(均P <0. 05)。肾实质SWV与血清TGF-β1水平呈正相关(r=0. 631,P <0. 05)。结论肾实质SWV和血清TGF-β1的表达会随慢性移植肾肾病的进展而升高,二者在慢性移植肾肾病诊断中有重要的应用价值。Objective To evaluate the change of shear wave velocity (SWV) of renal parenchyma and serum level of transforming growth factor beta 1 (TGF-β1) in the patients with chronic allograft nephropathy (CAN), and further evaluate the correlation between them. Methods A total of 60 patients with chronic allograft nephropathy confirmed by renal biopsy were selected and divided into three groups according to the degree of interstitial fibrosis and tubular atrophy of the transplanted kidney: group C1 (renal cortex involvement <25%, n=20), group C2(renal cortex involvement accounted for 26%-50%, n=20), group C3(renal cortex involvement >50%, n=20). 30 renal transplant recipients with normal renal function were enrolled for control group. The SWV of the renal were measured by virtual touch tissue quantification (VTQ) and the serum level of TGF-β1 were detected by enzyme linked immunosorbent assay (ELISA) in each group. Results Compared with control group, the SWV and serum TGF-β1 in case groups were significantly higher (P<0.05). SWV measured values: group C3 was the highest, group C2 was middle one and group C1 was the lowest (P<0.05). Statistically significant difference in serum TGF-β1 was observed among these three groups (P<0.05). The renal SWV and serum TGF-β1 had a significant positive correlation (r=0.631, P<0.05). Conclusions Both renal SWV and serum TGF-β1 increase as CAN progressed, which have high value in the diagnosis and treatment of CAN.
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