生物基质中四溴双酚A和六溴环十二烷分析方法研究进展  

Progress in the analytical methods of tetrabromobisphenol A and hexabromocyclododecane in biota matrix

作　　者：于紫玲 向明灯 马瑞雪 刘立婷 左优 林必桂 于云江 YU Ziling;XIANG Mingdeng;MA Ruixue;LIU Liting;ZUO You;LIN Bigui;YU Yunjiang(State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment,South China Institute of Environmental Sciences,Ministry of Ecology and Environment,Guangzhou,510655,China;School of Public Health,Jinzhou Medical University,Jinzhou,Jinzhou,121001,China;Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region,Ministry of Education,School of Environmental Science and Engineering,Chang'an University,Xi'an,710064,China)

机构地区：[1]生态环境部华南环境科学研究所国家环境保护环境污染健康风险评价重点实验室,广州510655 [2]锦州医科大学公共卫生学院,锦州121001 [3]长安大学环境科学与工程学院旱区地下水文与生态效应教育部重点实验室,西安710064

出　　处：《环境化学》2019年第3期503-512,共10页Environmental Chemistry

基　　金：国家自然科学基金(2160070653);广州市科技计划项目(20180410234);中央级公益性科研院所基本科研业务专项(PM-zx703-201803-068;PM-zx703-201803-071;PM-zx703-201701-030)资助~~

摘　　要：四溴双酚A(tetrabromobisphenol A,TBBPA)和六溴环十二烷(hexabromocyclododecane,HBCD)是目前世界上广泛使用的溴系阻燃剂,其对环境及人体的健康风险备受关注.本文对近年来生物基质(体液基质、生物组织等)中TBBPA和HBCD的分析方法,包括前处理方法和分析测定方法进行了综述.重点介绍了索氏提取法、液液萃取法、固相萃取法、加速溶剂萃取法等提取方法和气相色谱-质谱法、高效液相色谱-质谱法等仪器测定方法,并对各方法的优缺点进行了比较,为建立快速准确测定生物基质中TBBPA和HBCD的方法提供参考,为今后开展HBCD和TBBPA生物有效性以及健康风险评价研究提供方法依据.Tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD) are currently widely used brominated flame retardants. They have drawn great concern due to their potential harmful implications in human and wildlife. This article provides a comprehensive review of the available literature on TBBPA and HBCD analytical methods in biota matrix, including different sample preparation techniques as well as instrumental approaches. This review focuses on the most recent developments for pretreatment methods, including soxhlet extraction (SE), liquid-liquid extraction (LLE), soild phase extraction (SPE), and accelerated solvent extraction (ASE), and instrumental approaches, such as gas chromatography coupled to mass spectrometry (GC-MS) and high performance lipid chromatography coupled to mass spectrometry (LC-MS). The pros and cons of each method were compared. This review will provide accurate determination of TBBPA and HBCD in biota matrix, and scientific basis for the future research on bioavailabilty and health risk assessment of TBBPA and HBCD.

关 键 词：四溴双酚A 六溴环十二烷 生物基质 前处理 分析方法 

分 类 号：O657[理学—分析化学] X132[理学—化学]