液相色谱/串联质谱法测定水中8种亚硝胺方法优化研究  

Optimization of method for determination of 8 nitrosamines in water by liquid chromatography and tandem mass spectrometry

作　　者：杨阳[1] 王帅[1] 贾立明 陈鑫[3] YANG Yang;WANG Shuai;JIA Liming;CHEN Xin(East University of Heilongjiang,Haerbin,150066;Heilongjiang Provincial National Environmental Monitoring Station,Haerbin,150056;China National Environmental Monitoring Station,Beijing,100012)

机构地区：[1]黑龙江东方学院,哈尔滨150066 [2]黑龙江省环境监测中心站,哈尔滨1500562 [3]中国环境监测总站,北京100012

出　　处：《环境化学》2019年第3期708-711,共4页Environmental Chemistry

基　　金：松花江流域水生生物试点监测专项;2017年度黑龙江省高等教育教学改革研究项目(SJGY20170317);2017年度黑龙江东方学院科研项目(HDFHX170116);2017年度黑龙江东方学院科研项目(HDFHX170101);黑龙江省高等教育科学研究"十三五"规划课题(16G386)资助

摘　　要：本文使用液相色谱串联质谱法测定水中的8种亚硝胺类化合物,研究了样品的pH值、保存时间和离子源的选择对测定的影响.样品可采用固相萃取或直接进样的方式,使用内标法定量,液相色谱串联质谱法分析.经优化,各组分的响应良好,线性方程相关系数均大于0.995.进样量为10μL时,固相萃取法的检出限为5.47—8.24 ng·L^(-1),直接进样法的检出限为1.01—1.12μg·L^(-1).In this study, eight nitrosamines in water were determined by liquid chromatograpHy-tandem mass spectrometry. The effect of the pH, storage time and ion source selection on the assay was discussed. The samples can be determined by solid pHase extraction or direct injection, and quantified by internal standard method. Using liquid chromatograpHy tandem mass spectrometry, the response of each component was good, and the linear equation correlation coefficient was greater than 0.995. Liquid chromatograpHy tandem mass spectrometry has high sensitivity, good selectivity, fast and accurate. When the injection volume is 10 μL, the detection limit of solid pHase extraction is 5.47-8.24 ng·L^-1, and the detection limit of direct injection is 1.01-1.12 μg·L^-1.

关 键 词：液相色谱串联质谱法 亚硝胺 固相萃取 直接进样 

分 类 号：O657.63[理学—分析化学] X832[理学—化学]