中间体衍生化法与新农药创制  

The Intermediate Derivatization Method and Novel Agrochemical Discovery

作　　者：刘长令 关爱莹 李淼 杨吉春 LIU Chang-ling;GUAN Ai-ying;LI Miao;YANG Ji-chun(State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd., Shenyang 110021, China)

机构地区：[1]沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室,沈阳110000

出　　处：《农药》2019年第3期157-164,共8页Agrochemicals

摘　　要：针对新农药创制难度大、成功率低等特点,创建了"中间体衍生化法"。该方法的特点:在研究之初就考虑开发,选用便宜易得、安全环保的原料,采用易于产业化的反应,确保产品专利权稳定、性价比优势显著。大量实践证明该方法可大幅提高新农药创制的成功率。针对农业生产中重大病虫草害防治难题,采用"中间体衍生化法"设计新农药分子,发明了系列农药新品种,均获国内外发明专利授权,部分品种已实现产业化,并产生很好的经济、社会和环境效益,市场前景广阔。Aiming at the characteristics of great difficulty and low success rate in the discovery and development of novel agrochemicals,’the intermediate derivatization method’ was established. This method has the following advantages: the future development is concomitantly considered at early research stage, selecting economically available and environmentally friendly raw materials, adopting easy-to-industrialized chemical reactions, to ensure the product with stability of patent rights and high cost-effectiveness advantages. A lot of practices have proved that the method can improve significantly the success rate of new agrochemical discovery. Faced with prevention and control of major diseases/pests/weeds in agriculture, the intermediate derivatization method was employed to design new agrochemical molecules, the patents of a series of new agrochemical candidates were all granted by domestic and foreign countries, some products were successfully launched to market with good economic, social and environmental benefits, and broad market prospects.

关 键 词：中间体衍生化法 新农药创制 品种 专利 市场 

分 类 号：TQ460.3[化学工程—制药化工]