不同年龄段女性乳腺增生症临床病理特征分析  

Clinicopathological characteristics and risk factors of female breast hyperplasia in different age groups

作　　者：王斐[1] 申朔豪 刘丽媛[1] 王顽 蒋宏传[3] 滕理送 范志民[5] 耿翠芝[6] 金锋[7] 唐利立[8] 张建国[9] 王翔[10] 王殊[11] 段学宁[12] 于理想[1] 周飞[1] 相玉娟 黄淑亚 郑超 傅勤烨[1] 高德宗[1] 李亮[1] 马忠兵[1] 张强[1] 余之刚[1] Wang Fei;Shen Shuohao;Liu Li yuan;Wang Qi;Jiang Hongchuan;Teng Lisong;Fan Zhimin;Geng Cuizhi;Jin Feng;Tang Lili;Zhang Jianguo;Wang Xiang;Wang Shu;Duan Xuening;Yu Lixiang;Zhou Fei;Xiang Yujuan;Huang Shuya;Zheng Chao;Fu Qinye;Gao Dezong;Li Liang;Ma Zhongbing;Zhang Qiang;Yu Zhigang(Department of Breast Surgery, the Second Hospital of Shandong University, Jinan 250033, China;Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China;Breast Disease Center, Peking University People's Hospital, Beijing 100044, China;Breast Disease Center, Peking University First Hospital, Beijing 100034,China;Breast Disease Center, Guangdong Women and Children Hospital, Guangzhou 511400, China;Department of General Surgery, Beijing Chaoyang Hospital, Beijing 100043 ,China;Department of Surgical Oncology, the First Affliated Hospital of Zhejiang University, Hangzhou 310033, China;Department of Breast Surgery,the First Hospital of Jilin University, Changchun 130021,China;Breast Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011,China;Department of Breast Surgery f the First Affiliated Hospital of China Medical University, Shenyang 110001,China;Department of Breast Disease, Xiangya Hospital Central South University, Changsha 410008,China;Department of General Surgery , the Second Affiliated Hospital of Harbin Medical University, Harbin 150001,China)

机构地区：[1]山东大学第二医院乳腺外科,济南250033 [10]中国医学科学院肿瘤医院乳腺外科,北京100021 [11]北京大学人民医院乳腺中心,北京100044 [12]北京大学第一医院乳腺疾病中心,北京100034 [2]广东省妇幼保健院乳腺病防治中心,广州511400 [3]北京朝阳医院普通外科,北京100043 [4]浙江大学附属第一医院肿瘤外科,杭州310033 [5]吉林大学第一医院乳腺外科,长春130021 [6]河北医科大学第四医院乳腺中心,石家庄050011 [7]中国医科大学附属第一医院乳腺外科,沈阳110001 [8]中南大学湘雅医院乳腺科,长沙410008 [9]哈尔滨医科大学附属第二医院普通外科,哈尔滨150001

出　　处：《中华普通外科杂志》2019年第3期235-239,共5页Chinese Journal of General Surgery

基　　金：公益性行业科研专项(201502027);山东省自然科学基金重点项目(ZR2014HZ004);山东省自然科学基金(ZR2014H1D74).

摘　　要：目的探讨不同年龄段女性乳腺增生症的临床病理特征和相关风险因素分布。方法收集2015年1月至2016年12月在12家医院就诊的乳腺增生症患者的基本信息、临床查体、影像及病理资料,分为25-44岁青年组和45-75岁中老年组,比较两组差异。结果乳腺增生症患者3684例,青年组2291例和中老年组1393例,青年组及老年组患者临床分型均以乳痛型(50.3%比42.7%,P<0.001)多见,病理表现均以腺病为主(67.9%比61.7%,P<0.001).中老年组乳腺癌检出率高于青年组,肿块型患者为著(9.4%比4.2%,P<0.001)。两组间生育特征、生活习惯及疲劳焦虑抑郁等相关风险因素分布差异均有统计学意义(均P<0.05).结论乳腺增生症患者临床病理特征及相关风险因素分布因年龄不同而存在差异.Objective To analyze clinicopathological characteristics and the potential risk-related factors of female breast hyperplasia in different age groups. Method From Jan 2015 to Dec 2016 , patients diagnosed with breast hyperplasia in 12 hospitals were evaluated. All patients completed the self-designed questionnaires on women' health, including basic demographic information, clinic examination information, radiologic information and pathologic results. The patients were divided into a young group (<45 years old) and an elderly group ( from 45 to 75 years old). Results There were 3 684 cases of breast hyperplasia, including 2 291 cases in young group and 1 393 cases in elder group, respectively Clinically breast pain type were most commonly observed in both young and older groups ( 50. 3% vs. 42. 7%, P < 0. 001 ). While pathological research based on biopsy showed that breast adenopathy were the most common changes in both groups (67. 9% vs. 61. 7%, P <0. 001 ). More breast cancer cases were identified in elder group than that in young group, especially in clinically lump type patients ( 9. 4% vs. 4. 2%, P V 0. 001 ). Compared with elder group, patients in young group have different distribution characteristics regarding to fertility factors, lifestyle factors and psychology scale including anxiety and depression. Conclusion Distributions of clinicopathological characteristics and risk factors of female breast hyperplasia differ across different age groups.

关 键 词：乳腺疾病 年龄 病理学 临床 

分 类 号：R655.8[医药卫生—外科学]