稳心颗粒联合常规治疗对阵发性心房颤动患者心功能、心室重构及局部炎性反应的影响  

Effect of Wenxin granule combined with routine therapy on cardiac function, ventricular remodeling and local inflammatory response in patients with paroxysmal atrial fibrillation

作　　者：陈慧[1] 吴利云[1] 郑道国[1] 徐群威 Chen Hui;Wu Liyun;Zheng Daoguo;Xu Qunwei(Department of Cardiology, the Integrated Traditional Chinese and Western Medicine Hospital of Taizhou, Taizhou, Zhejiang 317523, China)

机构地区：[1]台州市中西医结合医院心内科,浙江省317523

出　　处：《中国基层医药》2019年第5期600-604,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨稳心颗粒联合常规治疗对阵发性心房颤动(PAF)患者心功能、心室重构及局部炎性反应的影响。方法选取2016年2月至2017年2月台州市中西医结合医院收治的116例PAF患者,按照随机数字表法分为对照组(55例)和联合组(6l例)。对照组给予常规盐酸胺碘酮片和马来酸依那普利片治疗,联合组在对照组基础上联合稳心颗粒治疗。比较两组患者临床疗效,对比分析两组患者治疗前后心功能、炎性反应水平及心室重构指标,观察并分析两组患者不良反应发生情况。结果联合组临床疗效总有效率为93.44%,明显高于对照组的76.36%,差异有统计学意义(χ^2=6.745,P<0.05)。联合组治疗后的左心房内径、左室内径短轴缩短率(FS)和心脏指数(CI)水平均明显高于对照组及治疗前(均P<0.05)。联合组治疗后p波离散度(Pd)水平为(47.16±0.80)ms;对照组治疗后Pd水平为(50.25±0.75)ms,联合组明显低于对照组及治疗前(t=21.395、48.318,均P<0.05)。联合组治疗后高敏C-反应蛋白(hs-CRP)和B型尿钠肽(BNP)水平分别为(7.12±2.71)mg/L、(118.43±11.16)ng/L;对照组治疗后hs-CRP和BNP水平分别为(11.21±2.89)mg/L、(123.65±11.27)ng/L,联合组均明显低于对照组及治疗前(t=7.865、2.504、8.585、8.752,均P<0.05)。联合组治疗后左心室射血分数(LVEF)水平高于对照组及治疗前(t=4.785、10.573,均P<0.05);左心室舒张末期内径(LVEDD)和左心室搏出量(LVSV)水平均明显低于对照组及治疗前(t=9.089、2.313、10.890、4.299,均P<0.05)。联合组不良反应总发生率为6.56%,略低于对照组的7.28%,但差异无统计学意义(χ^2=0.023,P>0.05)。结论稳心颗粒联合常规治疗PAF的临床疗效显著提升,心功能明显改善,可有效延缓心室重构,局部炎性反应水平显著下降,安全性高。Objective To explore the effects of Wenxin granule combined with conventional therapy on cardiac function, ventricular remodeling and local inflammatory response in patients with paroxysmal atrial fibrillation(PAF). Methods From February 2016 to February 2017, 116 patients with PAF in the Integrated Traditional Chinese and Western Medicine Hospital of Taizhou were randomly divided into control group(55 cases) and combined group(61 cases) according to the digital table.The control group was treated with routine amiodarone hydrochloride tablets and enalapril maleate tablets, and the combined group was treated with Wenxin granule on the basis of the control group.The clinical efficacy of the two groups was compared, and the cardiac function, the level of inflammatory reaction and the index of ventricular remodeling before and after treatment were compared and analyzed in the two groups.The adverse reactions were observed and analyzed in the two groups. Results The total effective rate in the combined group was 93.44%, which was significantly higher than 76.36% in the control group(χ^2=6.745, P<0.05). After treatment, the left atrial diameter, the FS and CI levels in the combined group were significantly higher than those in the control group and before treatment(all P<0.05). The level of Pd in the combined group after treatment was (47.16±0.80)ms,, which was significantly lower than that in the control group[(50.25±0.75)ms]and that before treatment(t=21.395, 48.318, all P<0.05). The levels of hs-CRP and BNP in the combined group were (7.12±2.71)mg/L,(118.43±11.16)ng/L, respectively, which were significantly lower than those in the control group[(11.21±2.89)mg/L,(123.6±11.27)ng/L]and before treatment(t=7.865, 2.504, 8.585, 8.752, all P<0.05). After treatment, the LVEF level in the combined group was higher than that in the control group and before treatment (t=4.785, 10.573, all P<0.05). The LVEDD and LVSV levels in the combined group were significantly lower than those in the control group and before treatmen

关 键 词：心房颤动 稳心颗粒 胺碘酮 马来酸依那普利 心脏功能试验 心室重构 炎症 疗效比较研究 

分 类 号：R541.75[医药卫生—心血管疾病]