老年人围手术期免疫功能损害的因素及影响  

Influence factors and mechanisms of perioperative immune impairment in elderly patients

作　　者：陈功 李潇潇 周磊 龚丽[1] 陈露 欧阳文[1] Chen Gong;Li Xiaoxiao;Zhou Lei;Gong Li;Chen Lu;Ouyang Wen(Department of Anesthesiology,the Third Xiangya Hospital,Central South University,Changsha 410000,China)

机构地区：[1]中南大学湘雅三医院麻醉科,长沙410000

出　　处：《国际麻醉学与复苏杂志》2019年第2期143-150,共8页International Journal of Anesthesiology and Resuscitation

摘　　要：围手术期免疫功能减退可导致老年患者术后感染的发病率增加、术后肿瘤转移复发率升高,并可能影响重要器官功能。因此,保护围手术期免疫功能具有重要的临床意义。文章总结了导致老年患者围手术期免疫功能减退的因素及影响。老化是导致老年人免疫功能减退的主要因素,手术进一步加重免疫功能损害,而麻醉剂也对免疫起到调节作用,但具体机制尚未完全阐明。临床研究方面需要进一步阐明如何调节个体易损性,减轻手术和麻醉对老年患者免疫功能的影响,为免疫功能的调控提供科学依据。Perioperative immune suppression leads to increases in the incidences of postoperative infection,tumor recurrence and impairment of organ functions.Therefore,it is important for them to protect perioperative immune function.The current review summarizes the factors that lead to perioperative immune suppression in the elderly and influences.Senescence is a main factor of immune suppression in elderly people.Surgery may further deteriorate immune function.Anesthetics are also involved in immune regulation.But the related mechanisms are not totally revealed.Further clinical investigations are needed to regulate vulnerability,reduce the influence of surgery and anesthetics on immune function and provide scientific evidence for immune regulation.

关 键 词：老年人 围手术期 免疫能力 

分 类 号：R614[医药卫生—麻醉学]