妊娠期肝内胆汁淤积症药物治疗机制及进展  

Mechanism and progress of drug therapy for intrahepatic cholestasis of pregnancy

作　　者：江杰妮 李佳平[1] 陈小凤[1] 王虎 张雪梅[1] 苟元钦 JIANG Jieni;LI Jiaping;CHEN Xiaofeng;WANG Hu;ZHANG Xuemei;GOU Yuanqin(Department of Obstetrics and Gynecology,Affiliated Hospital of North Sichuan Medical University, Sichuan Nanchong 637000,China)

机构地区：[1]川北医学院附属医院妇产科,四川南充637000

出　　处：《中国妇幼健康研究》2019年第3期378-381,共4页Chinese Journal of Woman and Child Health Research

摘　　要：妊娠期肝内胆汁淤积症的药物治疗目的是缓解瘙痒症状,降低血胆汁酸水平,改善肝功能,延长孕周,改善妊娠结局。目前临床常用的药物有熊去氧胆酸、S-腺苷蛋氨酸、多烯磷脂酰胆碱等。该文对妊娠期肝内胆汁淤积症药物治疗机制及进展进行综述。The purpose of drug treatment for intrahepatic cholestasis of pregnancy (ICP) is to relieve the symptom of itching,reduce blood bile acid level,improve liver function,extend gestational age,and improve pregnancy outcomes.At present,the commonly used drugs in the clinic include ursodeoxycholic acid,S-adenosylmethionine,and polyene phosphatidylcholine.This article reviewed the mechanism and progress of drug therapy for ICP.

关 键 词：妊娠期肝内胆汁淤积症 药物治疗 机制 进展 

分 类 号：R714.25[医药卫生—妇产科学]