细胞因子与糖尿病足血管发生的相关性研究  

Study on the correlation of cytokines and the angiogenesis of diabetic foot

作　　者：王中京[1] 邓艾平[1] 李居怡 徐子辉 吕晓玉[1] 张旭艳 付秀丽 李亚蓉[1] 宋春宇[1] Wang Zhongjing;Deng Aiping;Li Juyi;Xu Zihui;Lyu Xiaoyu;Zhang Xuyan;Fu Xiuli;Li Yarong;Song Chunyu(The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China)

机构地区：[1]华中科技大学同济医学院附属武汉中心医院,430014

出　　处：《国际内分泌代谢杂志》2019年第2期120-123,共4页International Journal of Endocrinology and Metabolism

基　　金：湖北省卫生计生委科研基金面上项目(WJ2017M183).

摘　　要：近些年来,基于细胞因子促进糖尿病足患者足部血管新生的疗法引起了人们的关注,而血管新生促进因子和抑制因子之间的动态平衡是维持伤口愈合正常发生的关键。通过介绍促血管生成细胞因子(血管内皮生长因子、低氧诱导因子-1、成纤维细胞生长因子、血小板衍生生长因子等)和抑血管生成细胞因子(色素上皮衍生因子和激肽释放酶结合蛋白)的作用机制,旨在为细胞因子治疗糖尿病足提供新的可行性方案。In recent years, cytokine-based therapy for diabetic foot has attracted much attention, and the dynamic balance between angiogenesis-promoting factors and inhibitors was the key to maintain the normal occurrence of wound healing. Mechanism of cytokines of angiogenesis-promoting (vascular endothelial growth factor, hypoxia-inducible factor-1, fibroblast growth factor, platelet-derived growth factor, et al.) and inhibitors (pigment epithelium derived factor and kallikrein binding protein ) were expounded. The aim was to provide a new protocol for the treatment of diabetic foot with cytokines.

关 键 词：糖尿病足 细胞因子 血管发生 

分 类 号：R587.2[医药卫生—内分泌]