2型糖尿病患者下肢动脉病变与颈动脉病变及心脑血管疾病的相关性研究  

Correlation between lower-extremity and carotid arterial diseases and cerebrovascular and cardiovascular diseases in patients with type 2 diabetes mellitus

作　　者：温志刚[1] 赵昶 何相成 陈丽娟 张晖[1] 吕丽珍[1] Wen Zhigang;Zhao Chang;He Xiangcheng;Chen Lijuan;Zhang Hui;Lyu Lizhen(Department of Endocrinology, Jiangmen Central Hospital, Jiangmen 529000, China)

机构地区：[1]江门市中心医院内分泌科,江门529000 [2]中山大学公共卫生学院,广州510080 [3]江门市第三人民医院内二科,江门529000 [4]江门市司前人民医院,江门529000

出　　处：《新医学》2019年第4期298-302,共5页Journal of New Medicine

摘　　要：目的探讨2型糖尿病患者下肢动脉超声结果与颈动脉超声结果的相关性,及两者与心脑血管疾病(CCVD)的相关性。方法选择338例2型糖尿病患者为研究对象,以问卷调查方式收集基本信息,并进行体格测量、生化检查和下肢动脉、颈动脉超声检查,对收集的信息进行横断面分析。结果 Gamma相关性分析显示,下肢动脉病变与颈动脉病变有关(Gamma=0.602,P <0.001)。Logistic回归显示,在校正年龄、病程、高血压病的影响后,颈动脉病变与CCVD相关(OR=2.58,95%CI 1.13～5.89,P <0.05),下肢动脉病变也与CCVD相关(OR=5.34,95%CI2.34～12.17,P <0.05)。结论 2型糖尿病患者下肢动脉病变与颈动脉病变有关,下肢动脉病变等级越高,颈动脉病变等级也越高,且两者均与CCVD的发生相关。Objective To investigate the correlation between the lower-extremity and carotid arterial ultrasound findings, and their association with the incidence of cerebrovascular and cardiocerebrovascular diseases( CCVD) in patients with type 2 diabetes mellitus. M ethods A total of 338 patients with type 2 diabetes mellitus were recruited in this clinical trial. Baselnie data were collected by questionnaire survey . Physical measurement, biochemical examinations and ultrasound examination of the lower-extremity and carotid arteries were conducted. The collected data were subject to cross-sectional analysis. Results Gamma correlation analysis showed a significant association between the severity of lower-extremity and carotid arterial diseases (Gamma = 0.602, P < 0.001). Logistic regression analysis demonstrated that CCVD was significantly associated with carotid arterial diseas(e OR = 2.58, 95%CI 1.13-5.89, P < 0.05) and lower-extremity arterial disease (OR = 5.34, 95%CI 2.34-12.17, P < 0.05) after adjusting the effects of age, course of disease and hypertension. Conclusions The lower-extremity arterial disease is correlated with the carotid arterial disease in type 2 diabetes mellitus patients. The higher grade of thoew elr-extremity arterial disease, the higher grade of carotid arterial disease. Lower-extremity arterial diseases and carotid arterial diseases are both correlated with the incidence of CCVD.

关 键 词：下肢动脉病变 颈动脉病变 2型糖尿病 心脑血管疾病 

分 类 号：R587.2[医药卫生—内分泌]