托吡酯对青中年偏头痛患者神经元放电及颅底动脉血液流变学的影响研究  

Effect of Topiramate on Neuronal Discharge and Hemorheology of Skull Base Artery in Young and Middle-aged Migraine Patients

作　　者：于莹 张娴[2] YU Ying;ZHANG Xian(Jiamusi Central Hospital,Jiamusi,Heilongjiang,154000,China)

机构地区：[1]佳木斯市中心医院,黑龙江佳木斯154000 [2]成都市第一人民医院,成都610000

出　　处：《中国初级卫生保健》2019年第4期101-102,共2页Chinese Primary Health Care

基　　金：四川省科技计划项目(2016SZ0914);中国健康促进基金会项目(KNKT-ZX-1801)

摘　　要：目的观察托吡酯对青中年偏头痛患者血液流变学及神经元放电的影响。方法选取2017年3月—2018年1月佳木斯市中心医院收治的112例青中年偏头痛患者随机分为对照组和观察组,每组各56例。对照组给予普萘洛尔治疗,观察组给予托吡酯治疗,治疗8 w,对比两组患者头痛发作、脑电图和颅底动脉血液流变学等情况。结果两组患者治疗后头痛发作次数、持续时间及疼痛程度具有显著差异(P<0.05);治疗后观察组患者α波频率变慢、δ波增多和θ波增多发生均高于对照组(P<0.05)。经治疗后,对照组患者大脑中动脉、大脑后动脉和基底动脉血流速度低于观察组(P<0.05)。结论托吡酯可减少偏头痛患者头痛发生,改善患者神经元放电及颅底动脉血流速度异常,适合临床推广。BJECTIVE To observe the effects of topiramate on blood rheology and neuronal discharge in patients with middle-aged migraine.METHODS A total of 112 patients with middle-aged migraine who were admitted to Jiamusi Central Hospital from March 2017 to January 2018 were randomly divided into control group and observation group.The control group was treated with propranolol.The patients were treated with topiramate for 8 weeks.The headaches,electroencephalogram and skull rheology hemorheology of the two groups were compared.RESULTS There were significant differences in the number,duration and pain of headache after treatment in the two groups(P<0.05).After treatment,the frequency ofαwave was slower,the increase ofδwave and the increase ofθwave were higher in the observation group than the control group(P<0.05).After treatment,the blood flow velocity of middle cerebral artery,posterior cerebral artery and basilar artery in the control group was lower than that in the observation group(P<0.05).CONCLUSION Topiramate could reduce the occurrence of headache in migraine patients,improve the neuronal discharge and abnormal blood flow velocity of the skull base,and which was suitable for clinical promotion.

关 键 词：托吡酯 偏头痛 神经元放电 血流速度 

分 类 号：R338.8[医药卫生—人体生理学]