导泻解毒方治疗急性有机磷农药中毒毒热蕴结型的临床研究  

A clinical study on treating acute organophosphorus pesticide poisoning of the Dure Yunjie type with the Daoxie Jiedu prescription

作　　者：张丹[1] 

机构地区：[1]泰安市中医医院,山东泰安271000

出　　处：《中医临床研究》2019年第8期120-122,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨中药导泻解毒方在急性有机磷农药中毒中的疗效。方法:选择口服急性有机磷农药中毒住院患者166例,随机分为实验组(56例)、生大黄粉组(55例)、甘露醇组(55例)。三组患者均应用常规治疗,实验组在此基础上加用中药导泻解毒方;生大黄粉组加用生大黄粉;甘露醇组加用甘露醇,均从胃管内注入以导泻排毒,观察三组患者的临床疗效。结果:三组患者在长托宁用药次数,首次排便时间,每日排便次数,心肌酶、肝功及血清胆碱酯酶(ChE)恢复时间,症状消失时间,住院时间比较,实验组均优于生大黄粉组及甘露醇组,而生大黄粉组又优于甘露醇组(P <0.05)。结论:急性有机磷农药中毒患者在常规治疗的基础上加用中药导泻解毒方,可明显加速肠道残存农药的排泄,减少并发症,较快改善临床症状,缩短住院天数,降低反跳率及病死率,值得临床推广应用。Objective: To investigate the efficacy of the Daoxie Jiedu prescription( 导泻解毒方) on acute organophosphorus pesticide poisoning. Methods: 166 patients were randomly divided into the experimental group(56 cases), raw rhubarb powder group(55 cases) and mannitol group(55 cases). Three groups were treated by routine treatment. The experimental group was given the Daoxie Jiedu prescription more. The raw rhubarb powder group was given raw rhubarb powder. The mannitol group was given mannitol. Results: The number of penehyclidine hydrochloride, the first time of defecation, the number of daily defecation, myocardial enzymes, liver fuction,ChE recovery time, the time of symptom disappearance and hospital time comparison in three groups in the experimental group were better than the raw rhubarb powder group and the mannitol group, and those in the raw rhubarb powder group were superior to the mannitol group(P<0.05). Conclusion: The Daoxie Jiedu prescription can obviously accelerate the excretion of residual pesticide in intestinal tract, promote recovery of complications, improve clinical symptoms, shorten the number of hospital days, reduce the anti-jump rate and mortality rate.

关 键 词：导泻解毒方 急性有机磷农药中毒 毒热蕴结型 

分 类 号：R139.3[医药卫生—劳动卫生]