世居高原藏、汉族人群冠心病与红细胞生理指标变化相关性的比较  

A comparative study on the relationship between coronary heart disease and the changes of physiological indexes of erythrocyte in Tibetan and Han population in the native of high altitude area

作　　者：邓勇 马晓峰 王红 许萍 陈娟 DENG Yong;MA Xiao-feng;WANG Hong;XU Ping;CHEN Juan(Cardiovascular and Cerebrovascular Disease Hospital of Qinghai Province,Xining,Qinghai 810012,China)

机构地区：[1]青海省心脑血管病专科医院干部保健科,青海西宁810012

出　　处：《岭南心血管病杂志》2019年第2期131-137,共7页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨比较世居高原藏、汉族人群冠状动脉粥样硬化性心脏病(冠心病)患者红细胞生理指标变化的差异。方法入选2014年1月至2016年12月于青海省心脑血管病专科医院行冠状动脉造影检查确诊为冠心病的患者562例,其中藏族患者240例为藏族冠心病组(藏族组);汉族患者322例为汉族冠心病组(汉族组);检测并记录患者的相关临床资料,并进行统计分析。结果在藏、汉两组患者总体对照中,血红蛋白(hemoglobin,HGB)、红细胞比容(hematocrit,HCT)、总胆红素(total bilirubin,TBIL)、D-二聚体(D-two dimer,D-Dimer)比较,差异无统计学意义(P>0.05)。藏族组凝血酶原时间(prothrombin time,PT)、活化部分凝血酶原时间(activated partial prothrombin time,APTT)、纤维蛋白原(fibrinogen,Fib)、红细胞计数(red blood cell count,RBC)、红细胞分布宽度(red blood cell distribution width,RDW)明显高于汉族组,TBIL、间接胆红素(indirect bilirubin,IBIL)明显低于汉族组,差异有统计学意义(P<0.05)。在海拔高度≤2000 m的地区,两组间APTT、Fib、D-Dimer、RBC、HGB、HCT、TBIL、直接胆红素(direct bilirubin,DBIL)、IBIL比较,差异均无统计学意义(P>0.05);藏族组RDW、PT明显高于汉族组,差异有统计学意义(P<0.05)。海拔高度2000～3000 m地区,两组间Fib、D-Dimer、RBC、HGB、HCT、RDW、DBIL比较,差异均无统计学意义(P>0.05);藏族组PT、APTT明显高于汉族组,TBIL、IBIL明显低于汉族组,差异有统计学意义(P<0.05)。海拔高度3000 m以上地区,两组间DDimer、RBC、HGB、HCT、DBIL、IBIL比较,差异均无统计学意义(P>0.05);藏族组PT、APTT、Fib、RDW明显高于汉族组,TBIL明显低于汉族组,差异有统计学意义(P<0.05)。藏族的PT、D-Dimer、RDW、TBIL、DBIL、IBIL在不同的海拔区间比较,差异无统计学意义(P>0.05);APTT、Fib、RBC、HGB、HCT指标均随海拔区间的升高而升高,差异有统计学意义(P<0.05)。汉族组PT、APTT、Fib、D-Dimer、RBC、Objectives To investigate the difference of erythrocyte physiological indexes in patients with coronary artery disease(CAD)from Tibetan and Han population living in high altitude area for generations.Methods From January 2014 to December 2016 in Cardiovascular and Cerebrovascular Disease Hospital of Qinghai Province,562 patients with CAD underwent coronary angiography,including 240 patients with CAD in Tibetan group(Tibetan group);322 patients with CAD in Han group(Han group).Related clinical data were detected,recorded and analyzed.Results In general,there were no statistical significant differences of hemoglobin(HGB),hematocrit(HCT),total bilirubin(TBIL),D-two dimer(D-Dimer)between Tibetan group and Han group(P>0.05);prothrombin time (PT),activated partial prothrombin time(APTT),fibrinogen(Fib),red blood cell count(RBC),red blood cell distribution width(RDW)in Tibetan group were significantly higher than those of Han group(P< 0.05);TBIL and indirect bilirubin(IBIL)in Tibetan group were significantly lower than those of Han group(P<0.05).In less than 2000 meters altitude area,APTT,Fib,D-Dimer,RBC,HGB,HCT,TBIL,direct bilirubin(DBIL) and IBIL showed no significant differences between the two groups (P>0.05).Tibetan group RDW and PT levels were significantly higher than that of the Han group(P<0.05).In altitude of 2000 to 3000 meters area,Fib,D-Dimer,RBC,HGB,HCT,RDW and DBIL showed no significant differences between the two groups;PT,APTT in Tibetan group were significantly higher than those of Han people(P<0.05);TBIL and IBIL in Tibetan group were significantly lower than those of the Han group(P<0.05).In altitude of higher than 3000 meters area,D-Dimer,RBC,HGB,HCT,DBIL and IBIL between the two groups showed no significant differences(P>0.05);PT,APTT,Fib,RDW of Tibetan group were significantly higher than those of Han group(P<0.05);TBIL of Tibetan group was significantly lower than that of Han group(P<0.05).In different altitude range,PT,D-Dimer,RDW,TBIL,DBIL,IBIL of Tibetan patients were not significantly differe

关 键 词：冠状动脉疾病 高原地区 红细胞 凝血功能 胆红素 藏族 汉族 

分 类 号：R541.4[医药卫生—心血管疾病]