壮药复方铁草胶囊(ZT)对肝癌小鼠扶正作用的研究  

Study on Strengthening Body Resistance of ZT with H_(22) Hepatoma-bearing Mouse

作　　者：邹静 郑作文[2] ZOU Jing;ZHENG Zuo-wen(Guangdong food and drug vocational college,Guangzhou 510520,China;Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广东食药品职业学院,广州510520 [2]广西中医药大学,南宁530001

出　　处：《海峡药学》2019年第3期16-18,共3页Strait Pharmaceutical Journal

摘　　要：目的探讨壮药复方铁草胶囊(ZT)对肝癌H_(22)荷瘤小鼠的扶正作用。方法采用腹腔注射CY致免疫低下的肝癌H_(22)荷瘤小鼠作为模型,设空白对照组、免疫抑制模型组和ZT高、中、低剂量组,以碳廓清率法、血清半数溶血值测定法测定小鼠的单核巨噬细胞吞噬功能和血清溶血素含量,以评价ZT的扶正作用。结果 ZT高、中剂量组均能显著提高CY致免疫低下的肝癌H_(22)荷瘤小鼠的单核巨噬细胞吞噬功能,与模型组比较P<0.01;ZT高剂量组能明显促进血清溶血素的生成,与模型组比较P<0.05。结论 ZT可提高免疫低下肝癌H_(22)荷瘤小鼠的免疫功能。OBJECTIVE To investigate the effect of ZT on strengthening body in H22 hepatoma-bearing mouse model.METHODS The CY-induced immune deficient mice,bearing with H22 hepatoma,were divided randomly into high,middle,low dose of ZT group,blank control group and model control group.Carbon clearance test and the serum hemonlysin assay were used to evaluate the phagocytosis function of mono macrophage system.RESULTS High and middle dose of ZT groups very significantly increased the monocytes phagocyteization of the CY-induced immune deficient mice bearing with H22 hepatoma,Compared with model control group P<0.01.High dose of ZT group significantly enhanced the concentrations of serum hemolysin,Compared with model control group P<0.05.

关 键 词：复方铁草胶囊 肝癌H22 免疫功能 

分 类 号：R965[医药卫生—药理学]