心脏磁共振评价肥厚型心肌病左心室功能与心力衰竭指标关系  

Evaluation of relationship between left ventricular function and heart failure indicator in hypertrophic cardiomyopathy by cardiac magnetic resonance

作　　者：刘新峰[1] 牟俊 王荣品[1] 曾宪春[1] 杨生佑[1] 赵细辉 Liu Xinfeng;Mu Jun;Wang Rongpin;Zeng Xianchun;Yang Shengyou;Zhao Xihui(Department of Radiology,Guizhou Provincial People's Hospital,Guiyang Guizhou 550002,China)

机构地区：[1]贵州省人民医院放射科,贵州贵阳550002

出　　处：《遵义医学院学报》2019年第1期71-74,共4页Journal of Zunyi Medical University

基　　金：贵州省科技厅-省医联合基金资助项目(NO:黔科合LH字[2015]7115);贵州省科技厅基金资助项目(NO:黔科合基础[2016]1096);贵州省人民医院青年基金资助项目(NO:GZSYQN [2017]15)

摘　　要：目的分析肥厚型心肌病(HCM)患者左心室功能参数值与心衰指标氨基末端B型脑利钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)的关系。方法对21例HCM患者(病例组)和16例健康志愿者(对照组)行心脏磁共振扫描,计算两组体表面积标准化后的左心室舒张末期容积(EDV)、收缩末期容积(ESV)、射血分数(EF)、每搏射血量(SV)、心肌质量(MM)等参数。利用电化学发光免疫分析法测定患者的NT-proBNP的含量。采用t检验及Pearson检验对左心室功能参数及NT-proBNP做统计学分析。结果 HCM患者EDV、ESV及SV分别为(70.77±13.25)mL/m^2、(19.46±4.30)mL/m^2、(45.00±6.29)mL/m^2,均低于对照组(P<0.05),EF值为(71.19±8.06)%,略高于对照组(P<0.05);心肌质量及NT-proBNP分别为(119.34±39.34)g/m^2,(869.35±249.02)ng/L,明显高于对照组(P<0.05)。HCM患者MM与NT-proBNP呈显著正相关(r=0.81,P<0.001),EF与NT-proBNP无明显相关性(P=0.468)。结论肥厚型心肌病患者左心室功能参数可间接反映心力衰竭程度,为临床判断病情及治疗选择提供基础依据。Objective To evaluate the relationship between the parameters of left ventricular function and the heart failure indicator (N-terminal pro-brain natriuretic peptide,NT-proBNP) in hypertrophic cardiomyopathy (HCM) patients. Methods 21 cases of HCM patients (case group) and 16 cases of healthy volunteers (control group) were performed by magnetic resonance (MR).The standardized parameters of end-diastolic volume (EDV),end-systolic volume (ESV),ejection fraction (EF),stroke volume (SV) and myocardial mass (MM) were calculated.The contents of NT-proBNP in patients were determined by electrochemical luminescence lmmune analysis.The independent sample t test and pearson correlation between left ventricular function and NT-proBNP were analyzed ( P<0.05 was set as significant). Results The EDV,ESV and SV of the HCM patients were (70.77+13.25)ml/ m^ 2,(19.46+4.30)ml/m ^2 and(45.00±6.29)ml/ m^ 2,which were lower than those of the control group.The EF was(71.19±8.06)%,which was slightly higher than that of the control group ( P<0.05 ). The MM and NT-proBNP of the HCM patients were (119.34 ± 39.34) g/m^ 2 and (869.35±249.02)ng/L,which were significantly higher than those of the control group.Pearson correlation analysis showed that the MM and NT-proBNP were significantly positive correlation in HCM patients( P <0.001).No significant correlation was found between the EF and the NT-proBNP ( P =0.468). Conclusion The function parameters of left ventricle in HCM patients can indirectly reflects the degree of the heart failure,which may be used as an evidence for evaluating the condition of heart function and therapeutic decision.

关 键 词：磁共振成像 心脏 肥厚型心肌病 氨基末端B型脑钠肽前体 

分 类 号：R445.2[医药卫生—影像医学与核医学]