都梁方中挥发油β-环糊精包合物的制备  

Preparation of β-cyclodextrin inclusion compounds of volatile oil in Duliang Decoction

作　　者：韦小翠 杨书婷 张焱[1] 朱宇超 颜媛媛 程建明 柳春娣 WEI Xiao-cui;YANG Shu-ting;ZHANG Yan;ZHU Yu-chao;YAN Yuan-yuan;CHENG Jian-ming;LIU Chun-di(Jiangsu Provincial Key Laboratory for Effective Substances of Chinese Materia Medica,College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Zhangjiagang Hospital Affiliated to Nanjing University of Chinese Medicine,Zhangjiagang 215600,China)

机构地区：[1]南京中医药大学药学院江苏省中药功效物质重点实验室,江苏南京210023 [2]南京中医药大学附属张家港医院,江苏张家港215600

出　　处：《中成药》2019年第4期721-726,共6页Chinese Traditional Patent Medicine

基　　金：江苏高校优势学科建设工程资助(2017)

摘　　要：目的制备都梁方中挥发油β-环糊精包合物。方法水蒸气蒸馏法提取挥发油后,分别用磁力搅拌法、高速分散法、超声法、研磨法制备β-环糊精、羟丙基-β-环糊精包合物。以挥发油与β-环糊精比例、包合温度、分散时间为影响因素,包合物收率、包合率、含油率为评价指标,正交试验优化制备工艺。然后,通过显微镜法、红外光谱法、差示扫描量热法进行表征。结果高速分散法、β-环糊精的包合效果最强。最佳条件为挥发油与β-环糊精比例1∶10,包合温度50℃,分散时间5 min,包合物收率71.8%,包合率63.5%,含油率8.35%。表征结果显示包合物成功形成。结论该方法合理可行,可用于制备都梁方中挥发油β-环糊精包合物。AIM To prepare the β-cyclodextrin inclusion compounds of volatile oil in Duliang Decoction.METHODS The volatile oil extracted by steam distillation method was prepared into β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion compounds by magnetic stirring,high-speed dispersion,ultrasonic and grinding methods,respectively.With volatile oil-(β-cyclodextrin)ratio,inclusion temperature and dispersion time as influencing factors,inclusion compound yield,inclusion rate and oil content as evaluation indices,orthogonal test was applied to optimizing the preparation process.Subsequently,characterization was accomplished by microscope,infrared spectroscopy and differential scanning calorimetry methods.RESULTS High-speed dispersion method and β-cyclodextrin demonstrated the strongest inclusion effects.The optimal conditions were determined to be 1∶10 for volatile oil-(β-cyclodextrin)ratio,50 ℃ for inclusion temperature,and 5 min for dispersion time,the inclusion compound yield,inclusion rate and oil content were 71.8%,63.5% and 8.35%,respectively.Characterization results revealed the successful formation of inclusion compounds.CONCLUSION This reasonable and feasible method can be used for preparing the β-cyclodextrin inclusion compounds of volatile oil in Duliang Decoction.

关 键 词：都梁方 挥发油 Β-环糊精包合物 制备 

分 类 号：R284.2[医药卫生—中药学]