定喘汤治疗支气管哮喘急性发作(热哮证)疗效观察  

Clinical Observation of Dingchuan Decoction Treating Acute Bronchial Asthma of Heat Syndrome

作　　者：闫小荣 贾金虎[2] YAN Xiaorong;JIA Jinhu(Jiuquan TCM Hospital,Jiuquan 735000,China;Jiuquan People's Hospital,Jiuquan 735000,China)

机构地区：[1]甘肃省酒泉市中医院,甘肃酒泉735000 [2]甘肃省酒泉市人民医院,甘肃酒泉735000

出　　处：《中医药学报》2019年第2期83-87,共5页Acta Chinese Medicine and Pharmacology

摘　　要：目的:观察定喘汤治疗支气管哮喘急性发作期(热哮证)的临床疗效。方法:将140例临床确诊为支气管哮喘急性发作期(热哮证)患者,按就诊顺序随机分为对照组和治疗组,对照组给予药物多索茶碱注射液、布地奈德福莫特罗吸入剂、溴已新注射液治疗,治疗组给予上述西医治疗基础上加服中药定喘汤,每日1剂,分2次服,治疗疗程12 d。两组患者在治疗前及治疗12 d时进行症状改善积分、FEV1%、FEV1/FVC%、呼气高峰流量(PEF)、12 d内病情控制率、症状缓解时间、有效率、无效率、显效率等方面进行比较,并观察不良反应。结果:两组患者治疗后症状积分均较前改善,但治疗组症状改善更为明显(P<0.05),两组患者治疗后肺功能FEV1%、FEV1/FVC均较治疗前改善,但治疗组改善更为明显(P<0.05),治疗组症状体征缓解时间明显小于对照组(P<0.05),两组治疗12 d时无效率及未控制率无显著性差异(P>0.05),完全控制率、部分控制率、有效率、显效率均明显优于对照组(P<0.05)。结论:定喘汤可显著改善支气管哮喘急性发作期(热哮证)患者临床症状,缩短症状缓解时间,改善肺功能,提高完全控制率、部分控制率、有效率、显效率,无严重不良反应,值得临床应用。Objective: To observe the clinical curative effect of Dingchuan Decoction on acute bronchial asthma of heat syndrome. Methods: 140 cases of acute bronchial asthma with heat syndrome were randomly divided into the treatment group and the control group. The control group was treated with Doxofylline Injection, Budesonide/Fomoterol Inhaler, and Bromhexine Injection;on which basis, the treatment group was also treated with Dingchuan Decoction. The treatment course was 12 days. Symptom improvement, FEV1%, FEV1/FVC%, peak expiratory flow rate(PEF), disease control rate within 12 days, symptom relief time, effective rate, inefficiency, and marked effective rate were compared in the two groups, and the adverse reactions were observed as well. Results: The symptom scores, FEV1%, and FEV1/FVC% were improved after the treatment in the two groups;in which the treatement group improved more( P <0.05). The relief time was earlier in the treatment group than that in the control group( P <0.05). There was no significant difference in the inefficiency and uncontrolled rate between the two groups after 12 days of the treatment( P >0.05);however, the treatment group was better than the control group in terms of the total control rate, the partial control rate, the efficiency rate, and the marked effective rate( P <0.05). Conclusion: Dingchuan Decoction can significantly improve the clinical symptoms of acute bronchial asthma of heat syndrome, shorten the symptom relief time, improve the function of lung, and increase the complete control rate, the partial control rate, efficiency, and marked effective rate. The therapy has no serious adverse reactions, which is worthy of clinical application.

关 键 词：支气管哮喘急性发作 定喘汤 热哮证 

分 类 号：R256.12[医药卫生—中医内科学]