血清TXNIP、Trx、PKCβ1水平与2型糖尿病患者颈动脉内中膜厚度的相关性分析  

Correlation between expression of serum TXNIP, Trx and PKCβ1 and carotid intima-media thickness in type 2 diabetic patients

作　　者：王海丽[1] 王洪[1] 白显树[1] 薄飞[1] 杜薇[1] 李凤娟 Hai-li Wang;Hong Wang;Xian-shu Bai;Fei Bo;Wei Du;Feng-juan Li(Department of Ultrasonography,Chengde Center Hospital,Chengde,Hebei 067000,China)

机构地区：[1]承德市中心医院超声诊断科,河北承德067000

出　　处：《中国现代医学杂志》2019年第8期94-98,共5页China Journal of Modern Medicine

摘　　要：目的探讨2型糖尿病(T2DM)患者血清中硫氧还蛋白相互作用蛋白(TXNIP)、硫氧还蛋白(Trk)与蛋白激酶Cβ1(PKCβ1)水平与颈动脉内中膜厚度(IMT)的相关性。方法选取2015年4月—2017年5月承德市中心医院就诊的114例T2DM患者作为观察组,并根据是否存在颈动脉内中膜增厚分为内中膜增厚亚组(83例)和内中膜非增厚亚组(31例),另选择同期114例健康体检者作为对照组。比较3组性别组成、年龄、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、吸烟情况、是否合并高血压、空腹血糖(FPG)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇(TC)、糖化血红蛋白水平(Hb A1c)、TXNIP、Trx、PKCβ1及颈动脉IMT值的差异。通过Logistic回归分析寻找影响颈动脉IMT的独立危险因素,通过Spearman相关性分析进一步确认TXNIP、Trx及PKCβ1与颈动脉IMT的相关性。结果观察组FPG、Hb A1c、TXNIP、Trx及PKCβ1颈动脉IMT值均高于对照组(P<0.05),内中膜增厚亚组各指标均高于内中膜非增厚亚组(P <0.05);多因素Logistic回归分析显示,Hb A1c[Ol^R=1.242,95%CI(1.104,1.457)]、TXNIP[Ol^R=1.794,95%CI(1.382,2.351)]、Trx[Ol^R=1.537,95%CI(1.343,2.185)]及PKCβ1[Ol^R=1.321,95%CI(1.132,1.646)]是颈动脉IMT的独立危险因素(P <0.05);同时TXNIP、Trx及PK Cβ1与颈动脉IMT值呈正相关(rs=0.586、0.368及0.413,P=0.013、0.029及0.032)。结论 TXNIP、Trx及PKCβ1是颈动脉IMT的独立危险因素,且均呈正相关。Objective To investigate the relationship between expression of serum TXNIP,Trx and PKCβ1 and carotid intima-media thickness(IMT)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 114 T2DM patients treated in our hospital from April 2015 to May 2017 were included in the observation group.According to the presence or absence of carotid intimal thickening,they were divided into two groups:intimal thickening sub-group(83 cases)and non-thickening intima sub-group(31 cases),and the other 114 cases of healthy subjects in the same period were included in the control group.The differences of sex composition,age,body mass index,systolic blood pressure,diastolic blood pressure,smoking status,hypertension,fasting blood glucose,triglycerides,low density lipoprotein,high density lipoprotein,total cholesterol,glycosylated hemoglobin(HbA1c),TXNIP,Trx,PKCβ1 and carotid IMT were compared.Logistic regression analysis was used to identify independent risk factors affecting carotid IMT.The correlation between TXNIP,Trx and PKCβ1 and carotid IMT was further confirmed by Spearman correlation analysis.Results For the fasting blood glucose,HbA1c,TXNIP,Trx,PKCβ1and carotid IMT value,the indicators of the observation group were higher than those of the control group(P<0.05),and those of the intimal thickening sub-group were higher than those of non-thickening intimal sub-group(P<0.05).Multivariate Logistic regression analysis showed that HbA1c[OR=1.242,95%CI(1.104,1.457)],TXNIP[O R=1.794,95%CI(1.382,2.351)],Trx[OR=1.537,95%CI(1.343,2.185)]and PKCβ1[OR=1.321,95%CI(1.132,1.646)]were independent risk factors of carotid artery IMT.At the same time,TXNIP,Trx and PKCβ1 showed positive correlation with carotid IMT(r=0.586,0.368,0.413,P=0.013,0.029,0.032).Conclusions TXNIP,Trx and PKCβ1 are independent risk factors of carotid artery IMT,and have positive correlation with the latter.

关 键 词：糖尿病 2型 颈动脉 硫氧还蛋白质类 蛋白激酶类 

分 类 号：R587.1[医药卫生—内分泌]