细菌对抗菌药物产生氧化应激的研究进展  

Research progress in oxidative stress induced by antibiotics in bacteria

作　　者：张家杰[1] 叶山亮[2] 喻玮 Zhang Jiajie;Ye Shanliang;Yu Wei(Department of Infectious Diseases,Zhejiang Provincial People′s Hospital,People′s Hospital of Hangzhou Medical College,Hangzhou 310014,China;Department of Gastroenterology,Guangdong General Hospital,Guangzhou 510080,China)

机构地区：[1]浙江省人民医院杭州医学院附属人民医院感染病科,310014 [2]广东省人民医院消化内科,广州510080

出　　处：《中华微生物学和免疫学杂志》2019年第2期157-160,共4页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金青年项目(81803589).

摘　　要：抗菌药物不仅可以通过与特定靶点相结合而发挥抗菌作用,也可通过诱导活性氧(reactive oxygen species,ROS)积累造成菌体氧化损伤。细菌对于氧化应激损伤,也有相应的防御机制,对ROS进行清除及损伤修复。然而细菌体内ROS的累积在抗菌药物杀菌过程中的作用机制却极其复杂。因此,本文对抗菌药物作用下细菌发生氧化应激的机制进行综述,并简要分析现有研究存在的问题及需要进一步解决的问题。Antibiotics can not only combine with specific targets,but also induce a cascade of reactive oxygen species(ROS)in bacteria.Antioxidant defense system plays an important role in scavenging ROS and repairing injury against oxidative stress.However,the mechanism of ROS accumulation in bacteria and the action of ROS are very complicated.Therefore,this paper reviewed the mechanisms of bacterial responding to oxidative stress in the existence of antibiotics.In addition,we analyzed the main problems lying in the current study and the issues needing further consideration.

关 键 词：活性氧 氧化应激 抗氧化 转录调控元件 

分 类 号：R378[医药卫生—病原生物学]