基于Buchwald-Hartwig反应合成N^6-芳氨基脱氧腺苷衍生物  

Synthesis of N^6-Arylamino-2’-deoxyadenosine via Buchwald-Hartwig Reaction

作　　者：时尚[1] 刘刚[1] 王盼港 胡军林 SHI Shang;LIU Gang;WANG Pangang;HU Junlin(School of Chemistry and Materials Science,Ludong University,Yantai 264039,China)

机构地区：[1]鲁东大学化学与材料科学学院,山东烟台264039

出　　处：《鲁东大学学报（自然科学版）》2019年第2期136-142,共7页Journal of Ludong University:Natural Science Edition

基　　金：山东省自然科学基金计划项目(ZR2013BM006)

摘　　要：N^6-芳氨基脱氧腺苷类化合物是一类重要的抗肿瘤药物分子,具有广泛的医疗价值.以2’-脱氧腺苷为原料,基于Buchwald-Hartwig反应,通过亚铜催化交叉偶联反应合成了一系列N^6-芳氨基脱氧腺苷衍生物(1a～1g),得到了一条高产率的N^6位修饰合成路线,为新型抗肿瘤药物合成提供参考.所得关键中间体及产物结构经IR,~1H NMR和^(13)C NMR得到确证.N6-arylaminodeoxyadenosine is an important kind of antitumor drugs with wildly medical activity.Using 2’-deoxyadenosine as raw material,based on Buchwald-Hartwig reaction,a series of compounds (1a^1g) were synthesized by cuprous-catalyzed cross-coupling reaction.Intermediates and title compounds were confirmed by IR, 1H NMR and 13 C NMR.A high-yield N 6-modified synthetic route was obtained,which provides a reference for the synthesis of novel anti-tumor drugs.

关 键 词：Buchwald-Hartwig反应 N6-芳氨基脱氧腺苷 亚铜盐催化 合成 

分 类 号：O626.413[理学—有机化学]