等离子喷涂生物涂层对病理性骨缺损愈合的应用研究  

Application Research of Plasma Sprayed Bioactive Coatings for Bone Regeneration under Pathological Conditions

作　　者：刘诗伟 李恺[1] 郑学斌[1] LIU Shi-wei;LI Kai;ZHENG Xue-bin(Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院上海硅酸盐研究所,上海200050 [2]中国科学院大学,北京100049

出　　处：《表面技术》2019年第4期1-9,共9页Surface Technology

基　　金：国家自然科学基金(51502328);上海市科委生物医药领域科技支撑项目(17441904400)~~

摘　　要：患者代谢性疾病(如骨质疏松症、糖尿病、痛风等)不利于体内骨植入体与周围骨的结合。基于不同疾病患者骨折部位骨微环境的特点,采用等离子喷涂技术制备的抗氧化应激生物涂层(针对骨质疏松)、抗感染-促成骨功能的生物涂层(针对糖尿病)和骨免疫调控涂层(针对痛风)能提高骨科植入器械与骨组织接触界面处的成骨能力,是增强植入体与骨结合的有效方法。研究了骨植入生物涂层对不同病理状态下效应细胞的影响,总结了材料表面性质调控效应细胞行为以及骨形成的规律,可为新型骨植入生物涂层的设计提供依据。等离子喷涂技术制备的含氧化铈的生物抗氧化涂层,可催化分解生物体内的过量活性氧簇,保护骨细胞成骨分化能力免于氧化应激的负面影响,有利于提高骨质疏松症下骨植入体的愈合能力。具抗感染与促成骨功能的硅酸钙基生物涂层能够抑制细菌在其表面的粘附与生长,降低植入体相关感染的几率,另外,该类涂层还能促进骨细胞成骨分化与矿化,提高骨植入体的成骨能力,有望应用于骨折合并糖尿病患者。等离子喷涂钛涂层表面微纳多级结构的构建以及生物涂层中锶/硼/铈等元素的掺入,有利于提高骨免疫性能,并促进骨细胞成骨分化,可用作炎症疾病下的骨缺损修复材料。The patient’s metabolic disease, such as osteoporosis, diabetes, gout, etc., impedes the osteointegration of the orthopedic implant. Based on the pathological features of the bone environment in fracture sites, developing novel biologic coatings on orthopedic implants, including anti-oxidative coating for osteoporosis, anti-bacterial coating for diabetes and immune-modulation coating for gout, is an effective way to enhance the osteointegration. To investigate the effects of orthopedic implant bio-coatings on cells which affect the pathological environment, and to summarize the relationship among surface characteristics and cellular behaviors and bone formation can provide a basis for the design of new orthopedic implant bio-coatings.Plasma sprayed ceria-based coatings with anti-oxidative properties can decompose excessive reactive oxygen species in living organisms by catalytic, and protect the osteogenic differentiation of osteoblasts from the negative effects of oxidative stress,which is beneficial for the osteointegration in osteoporosis. Calcium silicate-based bio-coatings with anti-infective and osteogenic functions can reduce the chance of implant-associated infection by inhibiting adhesion and growth of bacteria on their surface. In addition, this type of coating can also promote osteogenic differentiation and mineralization of osteoblasts and improve the osteointegration, exhibiting the potential to be applied to patients with fractures and diabetes. The micro/nano hierarchical structured Ti coatings and Sr/B/Ce modified bio-coatings demonstrate osteoimmune-modulation property and the improvement in osteoblastic differentiation, indicating that they can be used as bone repair materials under inflammatory diseases.

关 键 词：病理状态 骨科植入器械 等离子喷涂 生物涂层 骨整合 

分 类 号：TG174.442[金属学及工艺—金属表面处理]