中山地区住院患儿呼吸道博卡病毒感染的临床研究  

Clinical research on respiratory human bocavirus infecton in hospitalized children in Zhongshan area

作　　者：王丽[1] 黄娟[1] 莫庆仪[1] 周涛[1] WANG Li;HUANG Juan;MO Qingyi;ZHOU Tao(Department of Pediatrics,Boai Hospital of Zhongshan City,Zhongshan,Guangdong 528400,China)

机构地区：[1]广东省中山市博爱医院儿科,528400

出　　处：《检验医学与临床》2019年第8期1009-1011,1014,共4页Laboratory Medicine and Clinic

基　　金：广东省中山市卫生和计划生育委员会立项课题(2017A020068)

摘　　要：目的了解中山地区住院患儿呼吸道博卡病毒(HBoV)感染情况、混合感染及流行病学特点。方法选取2016年7月至2017年7月该院住院的急性呼吸道感染患儿共4 072例作为研究对象,同期完善相关病原学检查,并利用实时荧光定量PC(RT-PCR)对其鼻咽分泌物进行HBoV检测,收集相关资料。结果 4 072例患儿中,HBoV阳性204例,检出率为5.0%,男性患儿126例,阳性构成比61.8%,女性患儿78例,阳性构成比38.2%。<1岁、1～<3岁、3～<7岁,以及≥7岁患儿的HBoV检出率分别为2.04%、1.96%、0.81%、0.15%。从月份上来看,7、8月最高为11.7%,9月为11.3%。从季节上来看,夏、秋季分别为30.9%、25.5%。64例(31.4%)患儿存在混合感染,<1岁26例(12.7%),1～<3岁29例(14.2%),混合感染细菌的最多为42例(20.6%),双重感染24例(11.8%),混合感染的病原体,小于1岁混合感染中呼吸道合胞病毒9例,鼻病毒4例,1～<3岁肺炎支原体感染6例,流感嗜血杆菌6例,鼻病毒3例,3～<7岁及≥7岁主要为MP感染。结论 HBoV是中山地区呼吸道感染的病原体之一,主要感染婴幼儿,混合感染常见,但对病情无明显影响,流行季节在夏秋季,主要临床表现为发热、咳嗽,肝功损害、心肌损害并发症少。Objective To investigate the infection status,mixed infection and epidemiological characteristics of respiratory human bocavirus in hospitalized children in Zhongshan area.Methods From July 2016 to July 2017,a total of 4 072 children with acute respiratory infections were admitted to Boai Hospital in Zhongshan City.At the same time,the related etiology was improved and the HBoV was detected using RT-PCR to collect relevant data.Results A total of 204 children were positive with HBoV,the detection rate was 5.0%,the male were 126,the positive composition was 61.8%,the female children were 78,and the positive composition was 38.2%.The HBoV detection rates for children aged less than 1 year old,1 to <3 years old,3 to <7 years old,and ≥7 years old were 2.04%,1.96%,0.81%,and 0.15% respectively.In terms of months,the peak was 11.7 % in July and August and 11.3% in September.The summer and autumn seasons were 30.9% and 25.5 % respectively.64% of children(31.4%) had mixed infections,26 cases (12.7%) in the less than 1 year old group,29 cases (14.2%) in the 1-<3 year old group,the highest number of mixed infections is bateria,42 cases ( 20.6 %),and 24 cases of double infections (11.8%).The pathogens of mixed infections were 9 cases of mixed infections of respiratory syncytial virus less than 1 year old,4 cases of rhinovirus,6 cases of MP infection in 1 to <3 years old,6 cases of Haemophilus influenzae,3 cases of rhinovirus,3 to <7 years old and ≥ 7 years old is mainly MP infection.Conclusion HBoV is one of the pathogens of respiratory tract infection in Zhongshan area.It is mainly infected with infants and young children.Mixed infections are common,but there is no significant effect on the condition.In summer and autumn,the main clinical manifestations are fever,cough,liver work damage,and fewer complications of myocardial damage.

关 键 词：人博卡病毒 呼吸道感染 儿童 

分 类 号：R725.6[医药卫生—儿科]