肠内营养用于ICU重症胰腺炎的效果及对C反应蛋白、血红蛋白、清蛋白水平的影响  

Observation of enteral nutrition for severe pancreatitis in ICU and evaluation of C-reactive protein,hemoglobin and albumin levels

作　　者：郑珈琳 薛欣盛[2] ZHENG Jialin;XUE Xingsheng(Department of Intensive Care Unit,People′s Hospital of Anyue County,Ziyang,Sichuan 642350,China;Department of Intensive Care Unit,West China SecondHospital of Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川省资阳市安岳县人民医院ICU,642350 [2]四川大学附属华西二院ICU,成都610041

出　　处：《检验医学与临床》2019年第8期1064-1066,1070,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨肠内营养用于重症监护室(ICU)重症胰腺炎中的临床效果及对患者C反应蛋白、血红蛋白、清蛋白等水平的影响。方法选择2015年1月至2018年7月,该院ICU收治的100例重症胰腺炎患者,按照随机数字表法,分为对照组与观察组,各50例。对照组实施延迟肠内营养支持,观察组实施早期肠内营养支持,比较两组的临床疗效、症状缓解时间、住院时间、营养状况指标、并发症发生率、血清炎症因子指标、免疫功能指标。结果组间临床疗效比较,观察组的总有效率高于对照组(P<0.05)。观察组的发热消退时间、血淀粉酶恢复正常时间、住院时间均较对照组缩短(P<0.05)。治疗后,观察组的血红蛋白、清蛋白、前清蛋白、转铁蛋白营养状况指标水平均高于对照组(P<0.05),其CD3+、CD4/CD8、NK细胞免疫功能指标水平均高于对照组(P<0.05),其C反应蛋白、白细胞介素6、降钙素原、肿瘤坏死因子-α血清炎症因子指标水平均低于对照组(P<0.05)。组间并发症总发生率比较,观察组低于对照组(P<0.05)。结论在ICU重症胰腺炎患者中,实施肠内营养支持可有效改善患者的营养状况和免疫功能,抑制其机体内炎性反应,减少并发症发生,有利于提高患者的临床疗效,促进症状缓解。Objective To investigate the clinical effect of enteral nutrition in severe pancreatitis (intensive care unit,ICU) in intensive care unit (ICU) and its effect on C-reactive protein (CRP),hemoglobin (Hb) and albumin (albumin) levels.Methods One hundred patients with severe pancreatitis were selected from ICU and collected from Jan 2015 to Jul 2018.According to the method of random number table,the patients were divided into two groups:the control group and the observation group.The control group received delayed enteral nutrition support,and the observation group received early enteral nutrition support.The clinical efficacy,symptom relief time and hospitalization time were compared between the two groups.Nutritional status index,complication rate,serum inflammatory factor index,immune function index.Results Compared with the control group,the total effective rate of the observation group was higher than that of the control group ( P <0.05).The time of fever subsiding,the time of serum amylase returning to normal,the time of hospitalization were shorter than those of the control group ( P <0.05).The nutritional status of Hb,albumin,prealbumin and transferrin were higher than those of the control group ( P <0.05).The immunological function of CD3 +,CD4/CD8 NK cells was higher than that of the control group ( P <0.05).The serum inflammatory factors such as CRP,IL-6,PCT,TNF-α were lower than those of the control group ( P <0.05).Comparison of total incidence of complications between groups,the observation group was lower than the control group ( P < 0.05 ).Conclusion In patients with severe ICU pancreatitis,enteral nutrition support can effectively improve the nutritional status and immune function of the patients,inhibit the inflammatory reaction in the body,reduce the incidence of complications,and improve the clinical efficacy of the patients.Promote the remission of symptoms.

关 键 词：重症胰腺炎 重症监护室 肠内营养 

分 类 号：R563.7[医药卫生—呼吸系统]