H-FABP、cTnI及copeptin在老年急性非ST段抬高型心肌梗死患者早期诊断中的应用价值  

Application Value of H-FABP, c TnI and Copeptin in the Early Diagnosis of Elderly Patients with Acute Non ST Segment Elevation Myocardial Infarction

作　　者：谢学刚 宋强 和旭梅[1] 张松林[1] 胡志 王军[1] XIEXue-gang;SONGQiang;HE Xu-mei;ZHANG Song-lin;HUZhi;WANG Jun(Department of Structural Heart Disease,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710061,China)

机构地区：[1]西安交通大学第一附属医院结构性心脏病科,陕西西安710061

出　　处：《现代生物医学进展》2019年第3期465-468,551,共5页Progress in Modern Biomedicine

基　　金：陕西省社会发展科技攻关项目(S2015FS1082)

摘　　要：目的:研究心肌型脂肪酸结合蛋白(H-FABP)、肌钙蛋白I(cTnI)及和肽素(copeptin)在老年急性非ST段抬高型心肌梗死患者早期诊断中的应用价值。方法:选取2016年2月-2018年2月我院收治的老年急性非ST段抬高型心肌梗死患者60例为研究对象,记为观察组。另取同期于我院接受治疗的心绞痛患者50例记为对照组。分别比较患者H-FABP与cTnI阳性、阴性分布情况以及copeptin表达水平。绘制受试者工作特征曲线(ROC),分析H-FABP、cTnI、copeptin以及三项联合检测老年急性非ST段抬高型心肌梗死的早期诊断价值。结果:观察组患者H-FABP与cTnI阳性人数占比均高于对照组(P<0.05)。观察组患者copeptin表达水平高于对照组(P<0.05)。H-FABP、cTnI及copeptin等3个指标均具有一定的早期诊断价值,H-FABP+cTnI+copeptin联合检测的敏感度和特异度更高,分别为86.46%和87.15%。结论:老年急性非ST段抬高型心肌梗死患者H-FABP、cTnI、copeptin表达较高,联合检查上述三项指标水平可提高临床诊断价值。Objective: To study application value of heart fatty-acid-binding protein(H-FABP), troponin I(cTnI) and copeptin(copeptin) in early diagnosis of elderly patients with acute non ST segment elevation myocardial infarction. Methods: 60 patients with acute non ST segment elevation myocardial infarction who were treated in our hospital from February 2016 to February 2018 were selected as the study subjects, and they were recorded as observation group. 50 patients with angina pectoris who were treated in our hospital at the same time were selected and recorded as control group. The positive and negative distribution of H-FABP, cTnI and the expression level of copeptin in patients were compared. The receiver operating characteristic(ROC) was drawn, the early diagnostic values of H-FABP, cTnI, copeptin and three combined detection of acute non ST segment elevation myocardial infarction in elderly patients were analyzed. Results: The proportion of H-FABP and cTnI positive patients in the observation group was higher than the control group(P<0.05). The expression level of copeptin in observation group was higher than the control group(P<0.05). Three indexes such as H-FABP, cTnI and copeptin had certain early diagnostic value,and the sensitivity and specificity of combined detection with H-FABP+cTnI+copeptin were higher, which were 86.46% and 87.15% respectively. Conclusion: The expressions of H-FABP, cTnI and copeptin in elderly patients with acute non ST segment elevation myocardial infarction are higher, and the combined detection with the above three indexes can improve the value of clinical diagnosis.

关 键 词：老年 急性非ST段抬高型心肌梗死 心肌型脂肪酸结合蛋白 肌钙蛋白I 和肽素 

分 类 号：R542.22[医药卫生—心血管疾病]