复方辛夷滴鼻液联合氯雷他定治疗儿童变应性鼻炎的疗效及对患儿免疫功能指标的影响  

Efficacy of Compound Xinyidibi Ye Combined with Loratadine in the Treatment of Children with Allergic Rhinitis and Its Influence on the Immune Function

作　　者：孙先琳 刘华君 伏伶 王丽 甘新茹 SUN Xian-lin;LIU Hua-Jun;FU Ling;WANG Li;GAN Xin-ru(Department of Pediatrics in The General Hospital of Western Theater Command,Chengdu,Sichuan,610084,China)

机构地区：[1]西部战区总医院儿科,四川成都610084

出　　处：《现代生物医学进展》2019年第3期482-485,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(30901795)

摘　　要：目的:研究复方辛夷滴鼻液联合氯雷他定治疗儿童变应性鼻炎的疗效及对患儿免疫功能指标的影响。方法:选取2016年10月至2017年10月在我院接受诊治的126例变应性鼻炎患儿作为研究对象,参照随机数表法分成对照组、研究组,每组各63例。对照组患儿仅接受氯雷他定治疗,研究组患儿接受复方辛夷滴鼻液联合氯雷他定治疗,两组均持续治疗2个月。对比两组患儿的治疗效果及治疗前后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、血清白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)水平的变化。结果:治疗后,研究组治疗总有效率[95.2%(60/63)]显著高于对照组[81.0%(51/63)],差异有统计学意义(P<0.05);两组患儿的CD3^+、CD4^+、CD4^+/CD8^+水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组患儿的CD8^+水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组患儿的血清IL-4水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组患儿的血清IFN-γ水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。结论:复方辛夷滴鼻液联合氯雷他定治疗儿童变应性鼻炎的临床效果显著优于单用氯雷他定治疗,其能有效减轻机体炎症水平,提高机体免疫功能。Objective: To study the efficacy of compound Xinyidibi Ye combined with loratadine in the treatment of children with allergic rhinitis and its effect on the immune function of children. Methods: 126 cases of children with allergic rhinitis admitted to our hospital from October 2016 to October 2017 were selected as the research subjects. All the patients were divided into the control group and the study group according to random number table method with 63 cases in each group. The patients in control group were given loratadine alone, and the patients in study group received compound Xinyidibi Ye combined with loratadine for 2 months. The therapeutic effects, changes of CD3^+, CD4^+, CD8^+, CD4^+/CD8^+, CD8^+, serum IL-4 and IFN-γ levels of two groups were compared before and after treatment. Results: After treatment, the total effective rate of study group was 95.2%(60/63), which was significantly higher than that of the control group(81.0%, 51/63)(P<0.05), the levels of CD3^+, CD4^+and CD4^+/CD8^+of both groups were higher than those before treatment, which were higher in the study group than those of the control group, while the CD8^+of both groups were lower than those before treatment, which was lower in the study group than that of the control group(P<0.05);the levels of serum IL-4 in both groups after treatment were lower than those before treatment, which was higher in the study group than that of the control group, while the serum IFN-γ levels of both groups after treatment were higher than those before treatment, which was higher in the study group than that of the control group(P<0.05). Conclusions: Compound Xinyidibi Ye with loratadine is more effective in the treatment of children with allergic rhinitis than loratadine alone, and it can effectively reduce the level of inflammation and improve the immune function.

关 键 词：复方辛夷滴鼻液 氯雷他定 变应性鼻炎 免疫功能 炎症因子 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]